Centre for Safe Medication Practice and Research

About Centre for Safe Medication Practice and Research
Introduction

Medicines play an important role in clinical practice, contributing to the health and longevity of many patients. Yet many challenges prevent their optimal use, resulting in patient harm. Adverse drug events are a source of significant patient harm. There are worldwide initiatives to reduce adverse drug events. Under the strategic plan of the Department of Pharmacology & Pharmacy of The University of Hong Kong, the Centre for Safe Medication Practice and Research (CSMPR) was established in 2012 to foster research and development in medication safety in collaboration with local and international partners.

The mission of the CSMPR is to improve the health and quality of life of patients through interdisciplinary collaborative research that addresses questions central to medication safety. We focus on delivering innovative results that optimise the safe and effective use of medications. Drawing on the combined expertise of specialist resources from the Queen Mary Hospital (QMH), The University of Hong Kong (HKU) and other collaborative partners, the CSMPR provides a world-renowned platform for the training of health care professionals, patients and the general public on the safe and effective use of medications.

Our aim is to deliver high quality research with results relevant and applicable to health in real world settings, thus optimising and promoting the safe and effective use of medicine in Asia and beyond.

Centre leaders

front-photos4

Co-director (Left): 
Professor Ian CK Wong
Head & Professor

Co-director (Centre):
Mr. William CM Chui 
Hon Associate Professor

Research Lead (Right): 
Professor Esther WY Chan
Professor

Our mission

Our mission is to improve the health and quality of life of patients through interdisciplinary collaborative research that addresses questions central to medication safety.


Vision & Mission
Vision

To become a leading organisation in promoting safe medication practice and conducting safe medication research in Asia and beyond.

Mission
  • To improve the health and quality of life of patients through interdisciplinary collaborative research that addresses questions central to medication safety 
  • To develop new methodologies to advance safe medication practice and research 
  • To increase research capacity through the provision of training in pharmaceutical science, clinical pharmacology and pharmacoepidemiology in relation to medication safety 
  • To provide education to health care professionals, patients and the general public on the safe and effective use of medications 
  • To advocate for the adoption of safe medication practice in hospital and community settings

Partnerships & Collaborations
Partnerships
Collaborating Centres and Networks

Research areas & Focus
RESEARCH AREAS
  • Cardiology
  • Gastroenterology
  • Neuropsychiatry
  • Antimicrobials
  • Endocrinology
  • Emergency medicine
  • Safe medication use in special patient groups including children, elderly and pregnant women
  • Pharmacoeconomics
Drug preparation for clinical trials

Drug preparation for clinical trials


RESEARCH FOCUS
  • Clinical Research 
    • Effectiveness and safety of antipsychotics and sedating agents for the management of acute agitation in emergency department using different routes of drug administration

  • Pharmacoepidemiology 
    • Effectiveness and safety of medications by utilising various study designs and methodologies, including cohort, nested case-control, self-controlled case series, case-crossover, case-time-control study and propensity score analyses
    • Novel epidemiological methodologies to study the effectiveness and safety of medicine use and post-marketing surveillance of medications
    • Paediatric pharmacoepidemiology with a focus on neurodevelopmental disorders
    • Effectiveness and safety of medication use in general population and special patient groups 

  • Pharmacoeconomics 
    • Health economics and outcomes research on new drug utilisation
    • Decision analytical models for competing treatments
    • Discrete choice experiments to elicit consumers’ preferences and willingness-to-pay for new treatments
    • Healthcare resource utilisation in public hospitals in Hong Kong

Newsletter
Mar 2024 Issue CSMPR Newsletter Mar 2024Page1
Feb 2024 Issue CSMPR Newsletter Feb 2024Page1
Jan 2024 Issue CSMPR Newsletter Jan 2024Page1
Dec 2023 Issue CSMPR Newsletter Dec 2023Page1

Selected publications
2023
  • Shami J, Yan VKC, Wei Y, Alwafi H, Blais JE, Wan E., Wong CKH, Cheung KS, Leung WK, Wong MCS, Wong ICK, Chan EW*. Low‐dose aspirin does not lower the risk of colorectal cancer in patients with type 2 diabetes taking metformin. J Intern Med. 2023 Mar;293(3):371-383. doi: 10.1111/joim.13590. Epub 2022 Dec 13.
  • Ye X†, Huang C†, Wei Y, Li STH, Yan VKC, Yiu KH, Tse HF, Ma T, Qin S, Chui CSL, Lai FTT, Li X, Wan EYF, Wong CKH, Wong ICK*, Chan EW*. Safety of BNT162b2 or CoronaVac COVID-19 vaccines in patients with heart failure: A self-controlled case series study. Lancet Reg Health West Pac. 2023 Jan;30:100630. doi: 10.1016/j.lanwpc.2022.100630. Epub 2022 Nov 7.
  • Wan EYF, Wang B, Mathur S, Chan CIY, Yan VKC, Lai FTT, Chui CSL, Li X, Wong CKH, Li PH, Lau CS, Wong ICK, Chan EWY*. Molnupiravir and nirmatrelvir-ritonavir reduce mortality risk during post-acute COVID-19 phase. J Infect. 2023;S0163-4453(23)00117-2. doi:10.1016/j.jinf.2023.02.029.
  • Wan EYF, Yan VKC, Mok AHY, Wang B, Xu W, Cheng FWT, Lai FTT, Chui CSL, Li X, Wong CKH, Li PH, Cowling BJ, Hung IFN, Lau CS, Wong ICK, Chan EWY*. Effectiveness of molnupiravir and nirmatrelvir-ritonavir in hospitalized patients with COVID-19: A target trial emulation study. Ann Intern Med. 2023;M22-3057. doi:10.7326/M22-3057.
  • Huang C†, Wei Y†, Yan VKC, Ye X, Kang W, Yiu HHE, Shami JJP, Cowling BJ, Tse ML, Castle DJ, Chui CSL, Lai FTT, Li X, Wan EYF, Wong CKH, Hayes JF, Chang WC, Chung AKK, Lau CS, Wong ICK*, Chan EW*. Vaccine effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 Omicron infection and related hospitalisation among people with substance use disorder: a matched case-control study. Lancet Psychiatry. 2023 Apr 28:S2215-0366(23)00111-6. doi: 10.1016/S2215-0366(23)00111-6.
  • Lai FTT, Fan M, Huang C, Chui CSL, Wan EYF, Li X, Wong CKH, Cheung CL, Wong ICK*, Chan EWC*. Effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17. Nat Commun. 2023. 14, 1845. doi:10.1038/s41467-023-37556-z.
  • Lai FTT, Yan VKC, Ye X, Ma TT, Qin X, Chui CSL, Li X, Wan EYF, Wong CKH, Cheung CL, Li PH, Cheung BMY, Lau CS, Wong ICK, Chan EWY*. Booster vaccination with inactivated whole-virus or mRNA vaccines and COVID-19–related deaths among people with multimorbidity: a cohort study. Can Med Assoc J. Jan 2023, 195 (4) E143-E152; doi: 10.1503/cmaj.221068.

2022
  • Yan VKC†, Wan EYF†, Ye X, Mok AHY, Lai FTT, Chui CSL, Li X, Wong CKH, Li PH, Ma T, Qin S, Wong VKC, Tsang TC, Tsui SH, Chui WCM, Cowling BJ, Leung GM, Lau CS, Wong ICK*, Chan EWY*. Effectiveness of BNT162b2 and CoronaVac vaccinations against mortality and severe complications after SARS-CoV-2 Omicron BA.2 infection: a case-control study. Emerg Microbes Infect. 2022 Aug 18:1-48. doi: 10.1080/22221751.2022.2114854.
  • Wei Y, Yan V, Kang W, Wong I, Castle D, Gao L, Chui C, Man K, Hayes J, Chang WC, Chan EW*. Association of long-acting injectable antipsychotics and oral antipsychotics with disease relapse, health care use, and adverse events among people with schizophrenia. JAMA Netw Open. 2022;5(7):e2224163. doi:10.1001/jamanetworkopen.2022.24163.
  • Chan AYL, Ma T-T, Man KKC, Wong ICK. Attention-Deficit/Hyperactivity Disorder medication consumption in 64 countries and regions from 2015 to 2019: a longitudinal study. Data Analysis Protocol.
  • Xinning Tong, Chin-Yao Shen, Ha-Lim Jeon, Yihua Li, Ju-Young Shin, Xue Li, Edward Chia-Cheng Lai. Cardiovascular risk in patients with rheumatoid arthritis receiving targeted synthetic and biological disease-modifying antirheumatic drugs: a multi-centre retrospective cohort study. Common Data Protocol.
  • Kang W, Shami JJP, Yan VKC, Ye X, Blais JE, Li X, Lee VHF, Chui CSL, Lai FTT, Wan EYF, Wong CKH, Wong ICK and Chan EW. Safety of two-dose COVID-19 vaccination (BNT162b2 and CoronaVac) in adults with cancer: a territory-wide cohort study. J Hematol Oncol. 2022; 15 (66). DOI: 10.1186/s13045-022-01265-9
  • Ye X, Ma T, Blais JE, Yan VKC, Kang W, Chui CSL, Lai FTT, Li X, Wan EYF, Wong CKH, Tse HF, Siu CW, Wong ICK, Chan EW. Association between BNT162b2 or CoronaVac COVID-19 vaccines and major adverse cardiovascular events among individuals with cardiovascular disease. Cardiovasc Res. 2022 Jun 22:cvac068. doi: 10.1093/cvr/cvac068. Epub ahead of print.
  • Fung LWY, Zhao J, Yan VKC, Blais JE, Chan JCH, Li STH, Shami JJP, Kwan C, Yue Wei Y, Wong CKH, Li X, Chui CSL, Wan EYF, Lai FTT, Tse S, Cowling BJ, Wong ICK, Chan EW. COVID-19 vaccination preferences of university students and staff in Hong Kong. JAMA Network Open. 2022;5(5):e2212681. DOI:10.1001/jamanetworkopen.2022.12681
  • Lai F, Li X, Peng K, Huang L, Ip P, Tong X, Chui C, Wan EYF, Wong C, Chan EW, Siu DCW, Wong I. Carditis following Covid-19 vaccination with messenger RNA vaccine (BNT162b2) and inactivated virus vaccine (CoronaVac): a case-control study. Ann Intern Med. 2022 Jan 25. DOI: 10.7326/M21-3700.
  • Lai FTT, Huang L, Chui CSL, Wan EYF, Li X, Wong CKH, Chan EWW, Ma T, Lum DH, Leung JCN, Luo H, Chan EWY, Wong ICK. Multimorbidity and adverse events of special interest associated with CoronaVac (Sinovac) and Comirnaty (Pfizer-BioNTech). Nat Commun 13, 411 (2022). https://DOI.org/10.1038/s41467-022-28068-3.
  • Wan EYF, Chui CSL, Wang Y, Ng VWS, Yan VKC, Lai FTT, Li X, Wong CKH, Chan EWY, Wong CSM, Leung KSM, Ni MY, Valkenburg SA, Peiris JSM, Wu JTK, Cowling BJ, Ashcroft DM, Hung IFN, Leung GM, Wong ICK. Herpes zoster related hospitalization after inactivated (CoronaVac) and mRNA (BNT162b2) SARS-CoV-2 vaccination: A self-controlled case series and nested case-control study. Lancet Reg Health West Pac. 2022;21:100393. DOI:10.1016/j.lanwpc.2022.100393
  • Sing CW, Tang CTL, Chui CSL, Fan M, Lai FTT, Li X, Wan EYF, Wong CKH, Chan EWY, Hung IFN, Leung AYH, Cheung CL, Wong ICK. COVID-19 vaccines and risks of hematological abnormalities: nested case-control and self-controlled case series study. Am J Hematol. 2022 Jan 26. DOI: 10.1002/ajh.26478.
  • Yan VKC, Haendler M, Lau H, Li X, Lao KSJ, Tsui SH, Yap CYL, Knapp MRJ, Chan EW. Cost-effectiveness of midazolam versus haloperidol versus olanzapine for the management of acute agitation in the accident and emergency department. Value Health, 2022 Feb 9:S1098-3015(22)00003-1. DOI: 10.1016/j.jval.2020.06.020.
  • Shami JJP, Zhao JX, Pathadka S, Wan EYF, Blais JE, Vora P, Soriano-Gabarró M, Cheung KS, Leung WK, Wong ICK, Chan EW. Safety and effectiveness of low-dose aspirin for the prevention of gastrointestinal cancer in adults without atherosclerotic cardiovascular disease: a population based cohort study. BMJ Open, 2022 Feb 4;12(2):e050510. DOI: 10.1136/bmjopen-2021-050510.
  • Li X, Tong X, Wong ICK, Peng K, Chui CSL, Lai FTT, Wan EYF, Wong CKH, Leung WK, Chan EWY. Lack of inflammatory bowel disease flare-up following two-dose BNT162b2 vaccine: a population based cohort study. Gut. 2022 Feb 8:gutjnl-2021-326860. doi: 10.1136/gutjnl-2021-326860.
  • Blais JE, Wei Y, Knapp M, Wong ICK, Wei L, Chan EW. Trends in PCSK9 inhibitor utilization in the United States, Europe, and other countries: An analysis of international sales data. Am Heart J. 2022 Jun;248:13-20. doi: 10.1016/j.ahj.2022.02.008.

2021
  • Blais JE, Tong KY, Pathadka S, Mok MT, Wong ICK, Chan EW. Comparative efficacy and safety of statin and fibrate monotherapy: a systematic review and meta-analysis of head-to-head randomized controlled trials. PLOS One, 2021; 16(2):e0246480. DOI: 10.1371/journal.pone.0246480. Please click here for review protocol
  • Pathadka S, Yan VKC, Li X, Tse G, Wan EYF, Lau H, Lau WCY, Siu DCW, Chan EW, Wong ICK. Hospital and mortality in patients with heart failure treated with sacubitril/valsartan versus enalapril: a real-world, population-based study. Front Cardiovasc Med. 2021; (7):602363. DOI: 10.3389/fcvm.2020.602363.
  • Blais JE, Wei Y, Yap KKW, Alwafi H, Ma TT, Brauer R, Lau WCY, Man KKC, Siu CW, Tan KC, Wong ICK, Chan EW. Trends in lipid-modifying agent use in 83 countries. Atherosclerosis, 2021; 328: 44-51.
  • Chan EW, Lao KSJ, Lam L, Tsui MSH, Lui CT, Wong ACP, Graham CA Cheng RCH, Chung TS, Lam HF, Ting SM, Knott JC, Taylor DMcD, Kong DCM, Leung LP, Wong ICK. Intramuscular midazolam, olanzapine, or haloperidol for the management of acute agitation in the emergency department: a multi-center, double-blind, randomized clinical trial. EClinicalMedicine. 2021; (32)100751. DOI:10.1016/j.eclinm.2021.100751.
  • Zhao JX, Wang H, Li X, Yang H, Yan VKC, Wong KH, Guo Y, Cheung MK, Lip G, Siu CW, Tse HF, Chan EW. Importance of attributes and willingness-to-pay for oral anticoagulant therapy in patients with atrial fibrillation in China: A discrete choice experiment. PLoS Med. 2021; Aug 26;18(8):e1003730. DOI: 10.1371/journal.pmed.1003730.
  • Ye XX, Shami JJP, Yan VKC, Kang W, Blais JE, Zhao J, Lau WCY, Li W, Wong ICK, Chan EW. Global antiplatelet sales trend: a focus on P2Y12 inhibitors from 2008 to 2018. American Heart Journal Plus: Cardiology Research and Practice (2021). DOI: 10.1016/j.ahjo.2021.100020.
  • Wei Y, Zhao JX, Wong ICK, Wan EYF, Taylor DMcD, Blais JE, Castle DJ, Knott JC, Tse ML, Chow ATY, Chan EW. Relation of substance use disorders to mortality, accident & emergency department attendances, and hospital admissions: a 13-year population-based cohort study in Hong Kong. Drug and Alcohol Depend, 2021 Dec 1;229(Pt B):109119. DOI: 10.1016/j.drugalcdep.2021.109119.
  • Li X, Tong X, Yeung WWY, Peng K, Yum SHH, Chui CSL, Lai FTT, Wan EYF, Wong CKH, Chan EWY, Lau CS, Wong ICK. Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong. Ann Rheum Dis. 2021 Oct 22:annrheumdis-2021-221571. doi: 10.1136/annrheumdis-2021-221571.
  • Wan EYF, Chui CSL, Lai FTT, Chan EW, Xue L, Yan VKC, Gao L, Yu Q, Lam ICH, Chung RKC, Cowling BJ, Fong WC, Lau AYL, Mok VCT, Chan FLF, Lee CK, Chan LST, Lo D, Lau KK, Hung IFN, Leung GM, Wong ICK. Bell's Palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study. Lancet Infectious Diseases. 2021. First published: August 16, 2021. DOI: 10.1016/S1473-3099(21)00451-5.
  • Guo CG, Cheung KS, Zhang F, Chan EW, Chen LJ, Wong ICK, Leung WK. Delay in retreatment of Helicobacter pylori infection increases risk of upper gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2021. DOI: 10.1016/j.cgh.2020.03.071.
  • Wan EYF, Chui CSL, Lai FTT, Chan EW, Xue L, Yan VKC, Gao L, Yu Q, Lam ICH, Chung RKC, Cowling BJ, Fong WC, Lau AYL, Mok VCT, Chan FLF, Lee CK, Chan LST, Lo D, Lau KK, Hung IFN, Leung GM, Wong ICK. Bell's Palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study. Lancet Infectious Diseases. 2021. First published: August 16, 2021. DOI: 10.1016/S1473-3099(21)00451-5.
  • Brauer R, Alfageh B, Blais JE, Chan EW, Chui CSL, Hayes JF, Man KKC, Lau WCY, Yan VKC, Beykloo MY, Wang Z, Wei L, Wong ICK. Global psychotropic medicine consumption in 65 countries and regions from 2008 to 2019. Lancet Psychiatry. 2021 Dec;8(12):1071-1082. DOI: 10.1016/S2215-0366(21)00292-3.

2020
  • Chan AYL, Chan VKY, Olsson S, Fan M, Jit M, Gong M, Zhang SY, Ge M, Pathadka S, Chung CCY, Chung BHY, Chui CSL, Chan EW, Wong GHY, Lum TY, Wong ICK, Ip P, Li X. Access and unmet needs of orphan drugs in 194 countries and six areas: a global policy review with content analysis. Value Health, 2020. DOI: 10.1016/j.jval.2020.06.020. Please click here for review protocol
  • Lao KSJ, Zhao JX, Blais JE, Lam L, Wong ICK, Besag FMC, Chang WC, Castle DJ, Chan EW. Antipsychotics and risk of neuroleptic malignant syndrome: A population-based cohort and case-crossover study. CNS Drugs. 2020 Nov; (34) 11:1165-1175. DOI:10.1007/s40263-020-00767-9.
  • Yan VKC, Blais JE, Li X, Chui CSL, Li W, Yan BP, Knapp MRJ, Siu CW, Wong ICK, Chan EW. Trends in cardiovascular medicine use in 65 middle- and high-income countries. J Am Coll Cardiol, 2020; 77(7): 1021–1023. DOI: 10.1016/j.jacc.2020.12.025.
  • Lau WCY, Douglas IJ, Wong ICK, Smeeth L, Lip GYH, Leung WK, Siu CW, Cheung BMY, Mok MTC, Chan EW. Thromboembolic, bleeding, and mortality risks among patients with nonvalvular atrial fibrillation treated with dual antiplatelet therapy versus oral anticoagulants: a population-based study. Heart Rhythm. 2020; 17(1): 33–40. DOI:10.1016/j.hrthm.2019.07.034.
  • Zhao JX, Blais JE, Chui CSL, Suh IH, Chen EYH, Seto WK, Mok MTC, Yan VKC, Lau WCY, Wong ICK, Chan EW. Association between non-vitamin K antagonist oral anticoagulants or warfarin and liver injury: A cohort study. Am J Gastroenterol. 2020; 115(9): 1513–1524. DOI: 10.14309/ajg.0000000000000678.
  • Guo CG, Cheung KS, Zhang F, Chan EW, Chen L, Wong ICK, Leung WK. Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori: a territory-wide cohort study. Gut. 2020; 69(3):445–452. DOI:10.1136/gutjnl-2019-318352.
  • Cheung KS, Chan EW, Seto WK, Wong ICK, Leung WK. ACE (Angiotensin converting enzyme) inhibitors/angiotensin receptor blockers are associated with lower colorectal cancer risk: a territory-wide study with propensity score analysis. Hypertension. 2020. DOI: 10.1161/hypertensionaha.120.15317.
  • Kwok MK, Yu EYT, Wang Y, Chan EW, Wong ICK, Lam CLK. Blood pressure and risk of cardiovascular disease in UK biobank: A Mendelian randomization study. Hypertension, 2020; 77(2). DOI: 10.1161/HYPERTENSIONAHA.120.16138.
  • Lau WCY, Cheung CL, Man KKC, Chan EW, Sing CW, Lip G, Siu CW, Lam J, Lee A, Wong ICK. Association between treatment with apixaban, dabigatran, rivaroxaban, or warfarin and the risk of osteoporotic fractures among patients with atrial fibrillation: A population-based cohort study. Ann Intern Med. 2020 Jul 7;173(1):1-9. DOI: 10.7326/M19-3671.

2019
  • Blais JE, Chan EW, Law SWY, Mok MT, Huang D, Wong ICK, Siu CW. Trends in statin prescription prevalence, initiation, and dosing: Hong Kong, 2004–2015. Atherosclerosis. 2019; 280: 174–182. DOI: 10.1016/j.atherosclerosis.2018.11.015.
  • Li X, Blais JE, Wong ICK, Tam AWY, Cowling BJ, Hung IFN, Chan EW. Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011–2015. Eur J Clin Microbiol Infect Dis. 2019; 38(3):553–561. DOI: 10.1007/s10096-018-03459-x.
  • Huang D, Cheng Y, Wong YA; Yung SA, Tam AMF, Chan K, Lam S, Yiu K, Hai JJ, Lau CP, Chan EW, Chiang CE, Wong M, Cheung T, Cheung BMY, Tse HF, Chan PH, Siu CW. Thrombolysis in Myocardial Infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients. Circulation. 2019; 83(4): 809–817. DOI: 10.1253/circj.CJ-18-0308.
  • Cheung KS, Chen L, Chan EW, Seto WK, Wong ICK, Leung WK. Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187,897 patients. Gut. 2019; 68(11):1979–1985. DOI: 10.1136/gutjnl-2018-317714.
  • Cheung KS, Chan EW, Wong AYS, Chen LJ, Seto WK, Wong ICK, Leung WK. Metformin use and gastric cancer risk in diabetic patients after Helicobacter pylori eradication. J Natl Cancer Inst. 2019; 111(5): 484–489. DOI:10.1093/jnci/djy144.
  • Cheung KS, Chan EW, Chen LJ, Seto WK, Wong ICK, Leung WK. Diabetes mellitus increases risk of gastric cancer after Helicobacter Pylori eradication: A territory-wide study with propensity score analysis. Diabetes Care. 2019; 42(9):1769–1775. DOI: 10.2337/dc19-0437.
  • Wong CKH, Man KKC, Shi M, Chan EW, Ho CW, Tse E, Wong ICK, Lam C. Intensification with dipeptidyl peptidase-4 inhibitor, insulin, or thiazolidinediones and risks of all-cause mortality, cardiovascular diseases, and severe hypoglycemia in patients on metformin-sulfonylurea dual therapy: A retrospective cohort study. PLoS Med. 2019; 16(12):e1002999. DOI.10.1371/journal.pmed.1002999.

2018
  • Lam L, Anand S, Li X, Tse ML, Zhao J, Chan EW. Efficacy and safety of naltrexone for amfetamine and methamfetamine use disorder: A systematic review of randomized controlled trials. Clin Toxicology. 2018; 57(4) 225–233. DOI:10.1080/15563650.2018.1529317. Please click here for review protocol
  • Cheung KS, Chan EW, Wong AY, Chen L, Wong ICK, Leung WK. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for H. pylori: a population-based study. Gut. 2018; 67(1):28–35. DOI: 10.1136/gutjnl-2017-314605.
  • Law SWY, Wong AYS, Anand S, Wong ICK, Chan EW. Neuropsychiatric events associated with leukotriene-modifying agents: a systematic review. Drug Saf. 2018; 41(3): 253–265. DOI:10.1007/s40264-017-0607-1.
  • Law SWY, Wong AYS, Anand S, Wong ICK, Chan EW. Neuropsychiatric events associated with leukotriene-modifying agents: a systematic review. Drug Saf. 2018; 41(3): 253–265. DOI:10.1007/s40264-017-0607-1.
  • Law SWY, Lau WCY, Wong ICK, Lip GYH, Mok MTC, Siu CW, Chan EW. Sex-based differences in outcomes of oral anticoagulation in patients with atrial fibrillation. J Am Coll Cardiol, 2018; 72(3): 271–282. DOI: 10.1016/j.jacc.2018.04.066.
  • Cheung KS, Chan EW, Wong AYS, Chen L, Seto WK, Wong ICK, Leung WK. Aspirin and risk of gastric cancer after Helicobacter pylori eradication: A Territory-wide study. JNCI-J Natl Cancer Inst. 2018 Jul; 110(7):743–749. DOI:10.1093/jnci/djx267.
  • Cheung KS, Chan EW, Wong AY, Chen L, Wong ICK, Leung WK. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for H. pylori: a population-based study. Gut. 2018; 67(1):28–35. DOI: 10.1136/gutjnl-2017-314605.
  • Leung WK, Wong IOL, Cheung KS, Yeung KF, Chan EW, Wong AYS, Chen L, Wong ICK, Graham DY. Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals. Gastroenterology. 2018; 155(1): 67–75. DOI: 10.1053/j.gastro.2018.03.028.
  • Raman SR, Man KKC, Bahmanyar S, Berard A, Bilder S, Boukhris T, Bushnell GA, Crystal S, Furu K, Yang YK, Karlstad O, Kieler H, Kubota K, Lai EC, Martikainen JE, Maura G, Moore N, Montero D, Nakamura H, Neumann A, Pate V, Pottegård A, Pratt NL, Roughead EE, Saint-Gerons DM, Stürmer T, Su CC, Zoega H, Sturkenbroom M, Chan EW, Coghill D, Ip P, Wong ICK. Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases. Lancet Psychiatry. 2018; 5(10): P824–835. DOI:10.1016/S2215-0366(18)30293-1.

2017
  • Lau WCY, Chan EW, Cheung CL, Sing CW, Man KKC, Lip GYH, Siu CW, Lam JKY, Lee ACH, Wong ICK. Association between dabigatran vs warfarin and risk of osteoporotic fracture among patients with nonvalvular atrial fibrillation. JAMA 2017; 317(11):1151-1158. DOI: 10.1001/jama.2017.1363.
  • Lau WCY, Li X, Wong ICK, Man KKC, Lip GYH, Leung WK, Siu CW, Chan EW. Bleeding-related hospital admissions and 30-day readmissions in patients with non-valvular atrial fibrillation treated with dabigatran versus warfarin. J Thromb Haemost. 2017; 15(10): 1923-1933. DOI: 10.1111/jth.13780.
  • Man KKC, Chan EW, Coghill D, Ip P, Simonoff E, Chan PKL, Lau WCY, Schuemie MJ, Sturkenboom MCJM, Wong ICK. Prenatal antidepressant use and risk of attention-deficit/ hyperactivity disorder in offspring: a population-based cohort study. BMJ. 2017; 357:j2350:1-9. DOI: 10.1136/bmj.j2350.
  • Taylor DMcD, Yap C, Knott JC, Phillips GA, Karro J, Taylor SE, Chan EW, Castle, DC, Kong DCM. Midazolam-droperidol, droperidol or olanzapine for acute agitation: a randomised clinical trial. Ann Emerg Med. 2017; 69(3):318–326.e1. DOI: 10.1016/j.annemergmed.2016.07.033.
  • Wong AYS, Chan EW, Anand S, Worsley A, Wong ICK. Managing cardiovascular risk of macrolides: systematic review and meta-analysis. Drug Saf. 2017, 40(8): 663–677. DOI:10.1007/s40264-017-0533-2.

2016
  • Wong AYS, Wong ICK, Chui CSL, Lee EHM, Chang WC, Chen EYH, Leung WK, Chan EW. Association between acute neuropsychiatric events and Helicobacter pylori therapy containing Clarithromycin. JAMA Intern Med. 2016, 176(6):828-834. DOI:10.1001/jamainternmed.2016.1586.
  • Wong AYS, Root A, Douglas I, Chui CSL, Chan EW, Ghebremichael-Weldeselassie Y, Siu CW, Smeeth L, Wong ICK. Cardiovascular outcomes associated with use of clarithromycin: population based study. BMJ 2016; 352:h6926. DOI: 10.1136/bmj.h6926.
  • Chui CS, Chan EW, Wong AY, Root A, Douglas IJ, Wong IC. Association between oral fluoroquinolones and seizures: a self-controlled case series study. Neurology 2016, 86(18):1708-15. DOI: 10.1212/WNL.0000000000002633.
  • Chan PH, Huang D, Hai J, Li WH, Chan EW, Wong ICK, Lau CP, Chiang CE, Zhu J, Tse HF, Siu CW. Stroke prevention using Dabigatran in the very elderly with Atrial Fibrillation. Heart Rhythm 2016; 13(2):366-373. DOI: 10.1016/j.hrthm.2015.09.015.
  • Chan EW, Lau WCY, Siu CW, Lip GYH, Leung WK, Anand S, Man KKC, Wong ICK. Effect of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population wide cohort study. Heart Rhythm 2016; 13(8):1581-8. DOI: 10.1016/j.hrthm.2016.03.049.
  • He Y, Wong ICK, Li X, Anand S, Leung WK, Siu CW, Chan EW. The association between non-vitamin K antagonist oral anticoagulants and gastrointestinal bleeding: a meta-analysis of observation studies. Br. J. Clin. Pharmacol. 2016; 82(1): 285-300. DOI: 10.1111/bcp.12911.
  • Root A, Wong AYS, Ghebremichael-Weldeselassie Y, Bhaskaran K, Evans SJW, Brauer R, Wong ICK, Navratnam V, Douglas I. Evaluation of the risk of cardiovascular events with clarithromycin using both propensity score and self-controlled study designs. Br J Clin Pharmacol 2016; 82(2), 512-21. DOI: 10.1111/bcp.12983
  • Li X, Tse VC, Au-Doung LW, Wong ICK, Chan EW. The impact of ischaemic stroke on atrial fibrillation-related healthcare cost: a systematic review. EP Europace 2016; 19(6), 937-947. DOI: http://dx.doi.org/10.1093/europace/euw093.
  • Chan PH, Hai JJ, Chan EW, Li WH, Tse HF, Wong ICK, Lip GYH, Siu CW. Use of SAMe-TT2R2 score to predict good anticoagulation control with warfarin in Chinese patients with atrial fibrillation: Relation to ischemic stroke incidence. PLoS ONE 2016, 11(3): e0150674. DOI: 10.1371/journal.pone.0150674.
  • Chan PH, Huang D, Lau PC, Chan EW, Wong ICK, Lip GYH, Tse HF, Siu CW. Net clinical benefit of dabigatran over warfarin in patients with atrial fibrillation stratified by CHA2DS2-VASC and time in therapeutic range. Canadian Journal of Cardiology 2016; 32(10), 1247.e15-1247.e21. DOI: 10.1016/j.cjca.2016.01.016.
  • Lao KSL, Chui CSL, Man KKC, Lau WCY, Chan EW, Wong ICK. Medication safety research by observational study design. Int J Clin Pharm 2016; 38(3), 676-84. DOI: 10.1007/s11096-016-0285-6.
  • Li X, Tse VC, Lau WCY, Cheung BMY, Lip GYH, Wong ICK, Chan EWY. Cost-effectiveness of apixaban versus warfarin in Chinese patients with non-valvular atrial fibrillation: a real-life and modelling analysis. Plos ONE 2016; 11(6), e0157129. doi: 10.1371/journal.pone.0157129.
  • Lao KSJ, He Y, Wong ICK, Besag FMC, Chan EW. Tolerability and safety profile of cariprazine in treating psychotic disorders, bipolar disorder and major depressive disorder: a systematic review with meta-analysis of randomized controlled trials. CNS Drugs 2016; 30(11): 1043-1054. DOI: http://dx.doi.org/10.1007/s40263-016-0382-z. 
    Please click here for review protocol
  • Wong AYS, Chan EW, Anand S, Worsley AJ, Wong ICK. Managing cardiovascular risk of macrolides: systematic review and meta-analysis. Drug Saf 2016; 40(8):663-677. doi: 10.1007/s40264-017-0533-2.
    Please click here for review protocol

2015
  • Kendall J, Maconochie I, Wong IC, Howard R; on behalf of the DIASAFE study. A novel multipatient intranasal diamorphine spray for use in acute pain in children: pharmacovigilance data from an observational study. Emerg Med J. 2015; 32(4):269-73. DOI: 10.1136/emermed-2013-203226.
  • Chan EW, Lau WCY, Leung WK, Mok MTC, He Y, Tong TSM, Wong ICK. Prevention of Dabigatran Related Gastrointestinal Bleeding by Gastroprotective Agents: A Population-Based Retrospective Cohort Study. Gastroenterology 2015; 149(3):586-595.e3. DOI: 10.1053/j.gastro.2015.05.002.
  • Bielicki JA, Barker CIS, Saxena S, Wong ICK, Long PF, Sharland M. Not too little, not too much: problems of selecting oral antibiotic dose for children. BMJ. 2015; 3;351:h5447. DOI: 10.1136/bmj.h5447.
  • Chan PH, Li WH, Hai JJ, Chan KH, Tse HF, Cheung BMY, Chan EW, Wong ICK, Leung WK, Hung IFN, Lip GYH, Siu CW. Gastrointestinal Hemorrhage in Atrial Fibrillation Patients: Impact of Quality of Anticoagulation Control. Eur Heart J. 2015; 1:265-272. DOI: 10.1093/ehjcvp/pvv032
  • Man KKC, Tong HHY, Chan EW, Wong LYL, Wong ICK. Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies. Neurosci Biobehav Rev 2015; 49: 82-89. DOI: 10.1016/j.neubiorev.2014.11.020.
  • Lai ECC, Man KKC, Chaiyakunapruk N, Cheng CL, Chien HC, Chui CSL, Dilokthornsakul P, Hardy C, Hsieh CY, Hsu CY, Kubota K, Lin TC, Liu Y, Park BJ, Pratt N, Roughead EE, Shin JY, Watcharathanakij S, Wen J, Wong ICK, Yang YHK, Zhang Y, Setoguchi S. Brief Report: Databases in the Asia-Pacific Region: The Potential for a Distributed Network Approach. Epidemiology 2015; 26(6):815-20. DOI: 10.1097/EDE.0000000000000325.
  • He Y, Chan EW, Leung WK, Anand S, Wong ICK. Systematic review with meta-analysis: the association between the use of calcium channel blockers and gastrointestinal bleeding. Aliment Pharmacol Ther. 2015; 41(12):1246-1255. DOI: 10.1111/apt.13211.
  • Chui CSL, Wong ICK, Wong LYL, Chan EW. Association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies. J Antimicrob Chemother. 2015; 70(4):971-978. DOI: 10.1093/jac/dku507.
  • Man KKC, Chan EW, Douglas I, Ip P, Wong WHS, Coghill D, Leung LP, Tsui MSH, Wong ICK. Methylphenidate and the risk of trauma. Pediatrics. 2015; 135(1):40-48. DOI: 10.1542/peds.2014-1738.
  • Leung B, Jokanovic N, Tan EC, Jamsen KM, Emery T, Robson L, Manias E, Pitkälä KH, Chan EW, Bell JS. Prescribed Doses of Opioids in Long-Term Care Facilities. J Am Med Dir Assoc. 2015; 16(12):1100-1102. DOI: 10.1016/j.jamda.2015.09.005.
  • Garriga M, Pacchiarotti I, Kasper S, Zeller SL, Allen MH, Vázquez G, Baldacara L, San L, McAllister-Williams H, Fountoulakis K, Courtet P, Naber D, Chan EW, Fagiolini A, Möller HJ, Grunze H, Llorca PM, Jaffe RL, Yatham LL, Mazzei DH, Passamar M, Messer T, Bernardo M, Vieta E. Assessment and management of agitation in Psychiatry: Expert consensus. World J. Biol. Psychiatry 2015; 17(2):86-128. DOI: 10.3109/15622975.2015.
  • Cheung CL, Sahni S, Cheung BM, Sing CW, Wong IC. Vitamin K intake and mortality in people with chronic kidney disease from NHANES III. Clin Nutr. 2015; 34(2):235-40. DOI: 10.1016/j.clnu.2014.03.011.
  • Sing CW, Cheung CL, Wong ICK. Pharmacogenomics – how close/far are we to practising individualized medicine for children? Br J Clin Pharmacol. 2015; 79(3):419–428. DOI: 10.1111/bcp.12338.
  • Ho MH, Ho CW, Cheung E, Chan PH, Hai J, Chan KH, Chan EW, Leung GKK, Tse HF, Siu CW. Continuation of Dabigatran Therapy in ʺReal-worldʺ Practice in Hong Kong. PloS ONE. 2014; 9(8): e101245. DOI: 10.1371/journal.pone.010124.
  • Pratt N, Chan EW, Choi NK, Kimura M, Kimura T, Kubota K, Lai ECC, Man KKC, Ooba N, Park BJ, Sato T, Shin JY, Wong ICK, Kao Yang YH, Roughead EE. Prescription Sequence Symmetry Analysis: assessing risk, temporality and consistency for adverse drug reactions across data sets in five countries. Pharmacoepidemiol. Drug Saf. 2015; 24: 858–864. DOI: 10.1002/pds.3780.
  • Chan PH, Li WH, Hai JJ, Chan EW, Wong ICK, Tse HF, Lip GYH, Chung SW. Time in therapeutic range and percentage of international normalized ratio in the therapeutic range as a measure of quality of anticoagulation control in patients with atrial fibrillation. Can J Cardiol. 2015; published online ahead of print. DOI: 10.1016/j.cjca.2015.10.029.
  • Roughead EE, Chan EW, Choi NK, Kimura M, Kimura T, Kubota K, Lai ECC, Man KC, Nguyen TA, Ooba N, Park BJ, Sato T, Shin JY, Wang T, Griffiths J, Wong ICK, Yang YHK, Pratt NL. Variation in association between thiazolidinediones and heart failure across ethnic groups: Retrospective analysis of large healthcare claims databases in six countries. Drug Saf. 2015; 38(9):823-831. DOI: 10.1007/s40264-015-0318-4.
  • Cheung KKW, Wong ICK, Ip P, Chan PKL, Lin CHY, Wong LYL, Chan EW. Experiences of adolescents and young adults with ADHD in Hong Kong: treatment services and clinical management. BMC Psychiatry, 2015; 15(1):95. DOI: 10.1186/s12888-015-0478-x.
  • Ibrahim N, Wong ICK, Tomlin S, Sinha M, Rees L, Jani Y. Epidemiology of medicine-related problems in children with kidney disease. Pediatr Nephrol. 2015; 30(4): 623–633. DOI: 10.1007/s00467-014-2982-5.
  • Leung AYM, Lau HF, Chau PH, Chan EWY. Chinese Health Literacy Scale for Diabetes – Multiple-choice version (CHLSD-MC): A Validation Study. J Clin Nurs. 2015; 24(17-18):2679-2682. DOI: 10.1111/jocn.12902
  • Chan EW, Tang C, Lao SJ, Leung LP, Tsui SH, Ho HF, Wong G, Kong DCM, Knott JC, Wong ICK. The management of acute agitation in Hong Kong and comparisons with Australasia. Emerg Med Australas 2015; 27(6):542-548. DOI: 10.1111/1742-6723.12499.
  • Hsu WWQ, Chan EWY, Zhang ZJ, Lin ZX, Bian ZX, Hsia Y, Wong ICK. A survey to investigate attitudes and perceptions of Chinese medicine professionals in health information technology in Hong Kong. Eur J Integr Med. 2015; 7(1): 36-46. DOI: 10.1016/j.eujim.2014.10.001.
  • Hsu WWQ, Chan EWY, Zhang ZJ, Lin ZX, Bian ZX, Wong ICK. Chinese medicine students’ view on electronic prescribing: A survey in Hong Kong. Eur J Integr Med. 2015; 7(1): 47-54. DOI: 10.1016/j.eujim.2014.09.134.

2014
  • Chui CSL, Man KKC, Cheng CL, Chan EW, Lau WCY, Cheng VCC, Wong DSH, Yan-Kao YE, Wong ICK. An investigation of the potential association between retinal detachment and oral fluoroquinolones: a self-controlled case series study. J Antimicrob Chemother. 2014; 69(9):2563-2567. DOI: 10.1093/jac/dku145.
  • Wong AY, Hsia Y, Chan EW, Murphy DG, Simonoff E, Buitelaar JK, Wong ICK. The Variation of Psychopharmacological Prescription Rates for People With Autism Spectrum Disorder (ASD) in 30 Countries. Autism Res. 2014; 7(5):543-554. DOI: 10.1002/aur.1391.
  • Wong AY, Hsia Y, Chan EW, Murphy DG, Simonoff E, Buitelaar JK, Wong ICK. Psychopharmacological prescription for people with autism spectrum disorder (ASD): a Multinational study. Autism Res, 2014; 231(6):999-1009. DOI: 10.1007/s00213-013-3263-x.
  • Chan EW, Liu KQL, Chui CSL, Wing CW, Wong LYL, Wong ICK. Adverse Drug Reactions – Examples of detection of rare events using databases. Br J Clin Pharmacol. 2014; 80:855-861. DOI: 10.1111/bcp.12474.
  • Rashed AN, Wilton L, Lo CCH, Kwong BYS, Leung S, Wong ICK. Epidemiology and potential risk factors of drug-related problems in Hong Kong Paediatric wards. Br J Clin Pharmacol. 2014; 77(5):873–9. DOI: 10.1111/bcp.12270.
  • Wong AYS, Chan EW, Chui CSL, Sutcliffe AG and Wong ICK. The phenomenon of micronutrient deficiency among children in China: a systematic review of the literature. Public Health Nutr, 2014; 17(11):2605-2618. DOI: 10.1017/S1368980013002978.
  • Saxena S, Ismael Z, Murray ML, Barker C, Wong IC, Sharland M, Long PF. Oral penicillin prescribing for children in the UK: a comparison with BNF for Children age-band recommendations. Br J Gen Pract. 2014; 64(621):e217-22. DOI: 10.3399/bjgp14X677842.
  • Beckmann J, Hagemann U, Bahri P, Bate A, Boyd IW, Dal Pan GJ, Edwards BD, Edwards IR, Hartigan-Go K, Lindquist M, McEwen J, Moride Y, Olsson S, Pal SN, Soulaymani-Bencheikh R, Tuccori M, Vaca CP, Wong IC. Teaching Pharmacovigilance: the WHO-ISoP Core Elements of a Comprehensive Modular Curriculum. Drug Saf. 2014; 37(10):743-59. DOI: 10.1007/s40264-014-0216-1.
  • He Y, Chan EW, Man KKC, Lau WCY, Leung WK, Ho LM, Wong ICK. Dosage effect of histamine-2 receptor antagonist on the primary prophylaxis of non-steroidal anti-inflammatory drug (NSAID) associated peptic ulcers: a retrospective cohort study. Drug Saf. 2014; 37(9):711-721. DOI: 10.1007/s40264-014-0209-0.
  • Man KKC, Ip P, Hsia YF, Chan EW, Chui CSL, Lam MPS, Wong WHS, Chow CB, Yung A, Wong ICK. Attention-deficit/Hyperactivity disorder (ADHD) drug prescribing trend among school-aged children and adolescents in Hong Kong. J Atten Disord. 2014, Published online before print. DOI: 10.1177/1087054714536047.


Research Resources
Study Protocol

CSMPR has developed a study protocol template which includes the key elements of a big data research.

If you wish to collaborate with CSMPR on research projects, please refer to the template and complete the study protocol before developing the study.