Computational Metabolomics & Pharmacokinetics Laboratory

About Computational Metabolomics & Pharmacokinetics Laboratory
Introduction

Established under the Department of Pharmacology and Pharmacy, the Computational Metabolomics & Pharmacokinetics Laboratory (CMPK) is a cutting-edge research platform dedicated to advancing metabolomics and pharmacokinetics studies. As a pioneer in decoding global metabolic responses to biological stimuli, disease states, and therapeutic interventions, CMPK leverages high-resolution mass spectrometry technology to capture dynamic metabolic profiles. By integrating artificial intelligence for multidimensional data analysis, CMPK enhances its capabilities in understanding complex metabolic processes.

CMPK focuses on pharmacokinetics studies, analyzing the absorption, distribution, metabolism, and excretion (ADME) of therapeutic compounds to predict drug behavior accurately and optimize dosing strategies. By combining metabolomics' comprehensive characterization of endogenous metabolites with pharmacokinetics' quantitative analysis of xenobiotic compounds, CMPK develops innovative models that bridge molecular-level insights with clinical outcomes.

The multidisciplinary excellence at CMPK positions it as a dynamic force in expediting drug development pipelines, optimizing precision medicine strategies, and spearheading the discovery of innovative biomarkers for therapeutic monitoring across a broad spectrum of biomedical applications.


Core Strengths
  • Technology Integration: Combines mass spectrometry platforms with AI algorithms to enhance data mining capabilities.
  • End-to-End Services: Offers a one-stop solution from sample processing to data analysis.
  • Precision Medicine-Driven: Provides data-driven insights for disease diagnosis, drug development, and personalized medicine.
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Core Services
Service Platform Service Type Price per Sample (HKD$)
Price for Faculty of Medicine Users Regular Price
Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) systems

Q300 High-Throughput Metabolite Array Technology
High-Throughput Metabolomics Analysis
  • Enables simultaneous quantification of 324 metabolites, such as fatty acids, amino acids, bile acids, lipids, carbohydrates, drug metabolites, etc.
  • Achieves high sensitivity for a broad range of endogenous metabolites, supporting large-scale sample analysis.
Q300: $720

Bile Acid: $600

Lipids: $600
Q300: $1200

Bile Acid: $1000

Lipids: $1000
Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) systems
AI-Driven Metabolomics
  • Integrates high-resolution mass spectrometry data with advanced AI
  • Algorithms to discover novel metabolites and uncover hidden metabolic pathways.
  • Identifies patterns and correlations in complex datasets, enabling the detection of previously unknown biomarkers and disease-specific metabolic signatures.
  • Enhances understanding of metabolic mechanisms in diseases such as cancer, diabetes, and neurodegenerative disorders.
Q1000: $1200

An extended bile acid profile with over 150 BA species: $1200
Q1000: $2000

An extended bile acid profile with over 150 BA species: $2000
Pharmacokinetics Research
  • Comprehensive analysis of drug ADME.
  • Quantitative detection of drug metabolites to evaluate pharmacokinetic properties.
  • Supports pharmacokinetic modeling and optimization from preclinical to clinical stages.
$480 $800
Metabolomics Sample Processing & Data Support
  • Experimental Services:Experimental Services:
    • Metabolite Extraction: Processes various biological samples, such as serum, plasma, urine, tumor tissues, etc.
    • Targeted Quantitative Analysis: Precise detection of specific metabolites/markers, such as amino acids, bile acids, free fatty acids, lipids, drug metabolites, etc.
    • Global Metabolomic Profiling: Comprehensive metabolic profiling of human or animal samples.
  • Data Analysis & Interpretation:
    • Metabolomics data preprocessing, such as peak alignment, normalization, missing value imputation, etc.
    • Advanced bioinformatics analysis, such as metabolic pathway enrichment, network modeling, multi-omics integration, etc.
    • Provides visualized reports and biological interpretation.
Cost included in the above prices
Customized Solutions
  • Supports cross-disciplinary projects.
Please contact our specialists for project discussion and service quotation.