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Prof. Won Jong Kim
Professor,
Department of Chemistry,
Pohang University of Science and Technology,
Korea
Abstract:
Nitric oxide (NO) contributes to inflammation in rheumatoid arthritis (RA) and suppresses T cell activity in tumors. To counteract these effects, we developed nanoscavenger-based platforms for selective NO depletion. For RA, an injectable NO-scavenging gel reduced oxidative stress and inflammation, significantly alleviating symptoms when combined with dexamethasone. In oncology, NO-ROS scavenging micelles (NRSM) protected T cells from NO- and ROS-induced exhaustion, improving αPD-1 therapy efficacy and boosting survival rates. Additionally, LipoNOX liposomes restored T cell activation and enhanced tumor infiltration. These findings establish NO scavenging as a powerful strategy for treating RA and improving cancer immunotherapy.
Bio:
Prof. Won Jong Kim earned his B.Sc. degree from Hanyang University in Seoul, Korea, in 1998. He then pursued his M.S. and Ph.D. degrees in Biomolecular Engineering at the Tokyo Institute of Technology in 2004. During his graduate studies, he worked under the guidance of Professors T. Akaike and A. Maruyama, developing a polymer-mediated DNA detection system. After completing his doctoral studies, Prof. Kim served as a postdoctoral fellow at the University of Utah from 2004 to 2007, under the supervision of Professor Sung Wan Kim. He is currently the esteemed Mueunjae Chaired Professor in the Department of Chemistry at POSTECH. Prof. Kim has published over 200 articles in prestigious journals, delivered over 80 talks, and received numerous prestigious awards, including the PSK-Mid-career Researcher Academy Award. Additionally, Prof. Kim serves as an Associate Editor for WIRES: Nanomedicine and Nanobiotechnology and the newly launched journal Nanotheranostics. He is also a member of the editorial board for Materials Today Chemistry.
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