Dr. George Pak-Heng Leung
Associate Professor
Dr. George Pak-Heng Leung
Department of Pharmacology and Pharmacy
The University of Hong Kong
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Dr. George Leung and his research associates

Associate Professor

Dr. George Pak-Heng Leung
(梁栢行)

BPharm, PhD

Memberships:

  • Broad member of Pharmacy and Poison Board of Hong Kong
  • Chairman of Examination Committee, Pharamcy and Poison Board of Hong Kong
  • Tresurer of Asian Society for Vascular Biology
  • Council member of Institute of Cardiovascular Science and Medicine, HKU
  • Member of Research Centre of Heart, Brain, Hormone and Healthy Aging, HKU
  • Member of The American Physiological Society
  • Member of Hong Kong Pharmacology Society

Editorships:

  • Cardiology and Angiology: An International Journal
  • Cardiovascular Pharmacology: Open Access
  • International Journal of Pharmacological Sciences
  • Frontiers in Cardiovascular and Smooth Muscle Pharmacology

Biography

Dr. George Leung obtained his bachelor degree of pharmacy from the Chinese University of Hong kong. He pursued his PhD at the Department of Physiology, The Chinese University of Hong Kong, followed by two years post-doctoral training at the Department of Medicine, The Johns Hopkins University. He joined the Department of Pharmacology and Pharmacy, The University of Hong Kong as the Research Assistant Professor in 2003. He is currently Associate Professor of the Department.

His research focuses on the nucleoside transporters and cardiovascular pharmacology. He is also interested in traditional herbal medicine. He has published over 80 full length papers in international scientific journals including British Journal of Pharmacology, European Journal of Pharmacology, Biochemical Pharmacology, American Journal of Physiology and Circulation Research. He was the recipient of the Young Physiologist Scheme of the Physiological Society of UK in 1999. He is currently the treasurer of the Asian Society for Vascular Biology. He also serves as the reviewers for journals such as Biochemical Pharmacology, Clinical & Experimental Pharmacology & Physiology and American Journal of Physiology.

Honours and Awards

  • Teaching Medal, Faculty of Medicine, The University of Hong Kong (year 2009)

My Research Interests

  • Regulation of ion channels in vascular smooth muscle cells and endothelial cells
  • Physiology and pharmacology of nucleoside transporters and drug transporters in cardiovascular system
  • Interaction of western medicine and tradition herbal medicine

Publications Highlights

Li RWS, Yang C, Sit ASM, Kwan YW, Lee SMY, Hoi MPM, Chan SW, Hausman M, Vanhoutte PM, Leung GPH. (2014).
Uptake and protective effects of ergothioneine in human endothelial cells. Journal of Pharmacology and Experimental Therapeutics 350(3):691-700. Impact factor: 3.891

This paper reports the potential protective effect of ergothioneine, which is a chemical abundant in mushroom, on blood vessel. The experimental findings show that ergothioneine can produce potent antioxidant effect and preserve endothelial cell functions in oxidative stress and diabetic conditions.

Li RWS, Yang C, Kwan YW, Chan SW, Lee SMY, Leung GPH. (2013)
Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Frontiers in Cardiovascular and Smooth Muscle Pharmacology, 4:14. Impact factor: 3.802

This paper reports the presence of organic cation transport-3 and plasma membrane monoamine transporter in vascular smooth muscle cells. These transporters are supposed to play a critical part in vascular functions by fine-tuning the local concentration of 5-HT in the vicinity of 5-HT2 receptors in vascular smoothe muscle cells.

Leung GPH, Tse CM & Man RYK (2007).
Characterization of adenosine transport in H9c2 cardiomyoblasts. International Journal of Cardiology 116: 186-93. Impact factor: 7.708

This papers is about the characterization of adenosine transport system in H9C2 cardiomyoblasts, which are commonly used as a cell model of heart. The exceptionally high expression level of ENT-2 in H9c2 cells raises questions regarding the use of H9c2 cells as a model for physiological adenosine activity in the heart. Furthermore, this study may form the basis for further investigation into the effect of cell differentiation and protein kinases on the regulation of nucleoside transporters.

Leung GPH, Man RYK & Tse CM (2005).
Effect of Thiazolidinediones on Equilibrative Nucleoside Transporter-1 in Human Aortic Smooth Muscle Cells. Biochemical Pharmacology 70: 355-62. Impact factor: 4.705

This paper reports the effect of thiazolidinediones, which are anti-diabetic agents, on ENT1. The experimental findings suggests that one of the thiazolidinediones troglitazone may enhance the vasodilatory effect of adenosine by inhibiting ENT1. Troglitazone may serve as a lead compound for the development of a novel inhibitor of ENT1

 

Selected Publications

  • Li RWS, Cheung AC, Cheung KH, Shan L, Zhang Z, Wang Y, Yang C, Kwan YW, Lee SMY, Hoi MPM, Chan SW, Leung GPH (2015). Relaxation effect of a novel danshensu/tetramethylpyrazine derivative on rat mesenteric arteries. European Journal of Pharmacology 761:153-160. (impact factor: 2.684)
  • Li RWS, Yang C, Chan SW, Hoi MPM, Lee SMY, Kwan YW, Leung GPH. (2014). Relaxation effect of abacavir on rat basilar arteries. PLOS One 10(4):e0123043. (impact factor: 3.534)
  • Yang C, Yang J, Xu X, Yan S, Pan S, Pan X, Zhang C, Leung GPH. (2014).Vasodilatory effect of 14,15-epoxyeicosatrienoic on mesenteric arteries in hypertensive and aged rats. Prostaglandins and Other Lipid Mediators 112:1-8. (impact factor: 3.708)
  • Li RWS, Yang C, Sit ASM, Lin SYT, Ho EYW & Leung GPH (2012). Physiological and Pharmacological roles of vascular nucleoside transporters. Journal of Cardiovascular Pharmacology 59:10-5. (impact factor: 2.287)
  • Yang C, Kwan YW, Au AL, Poon CC, Zhang Q, Chan SW, Lee SM & Leung GPH (2010). 14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery. Prostaglandins and Other Lipid Mediator 93:44-51. (impact factor: 2.705)
  • Li RWS, Seto SW, Au ALS, Kwan YW, Tse CM, & Leung GPH (2009). Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells. European Journal of Pharmacology 612: 15-20. (impact factor: 2.516)
  • Yang C, Kwan YW, Seto SW & Leung GPH (2008). Inhibitory effects of epoxyeicosatrienoic acids on volume-activated chloride channels in rat mesenteric arterial smooth muscle. Prostaglandins and Other Lipid Mediator 87: 62-7. (impact factor: 2.705)
  • Li RWS, Man RYK, Vanhoutte PM & Leung GPH (2008). Stimulation of ecto-5'nucleotidase in human umbilical vein endothelial cells by lipopolysaccharide. American Journal of Physiology Heart and Circulation Physiology 295:H1177-81. (impact factor: 3.708)
  • Li RWS, Tse CM, Man RYK, Vanhoutte PM & Leung GPH (2007). Inhibition of human equilibrative nucleoside transporters by dihydropyridine-type calcium channel antagonists. European Journal of Pharmacology 568: 75-82. (Impact factor: 2.516)
  • Leung GPH, Man RYK & Tse CM (2005). D-Glucose up-regulates adenosine transport in cultured human aortic smooth muscle cells. American Journal of Physiology Heart Circulation Physiology 288, H2756-62. (impact factor: 3.708)

Funding

  • General research fund, RGC: Protective effect of ergothioneine on endothelial cell function against oxidative stress; $840,940 (Nov 2010 to Oct 2012)

  • General research fund, RGC: Abacavir, an antiviral nucleoside analogue, increases the risk of cardiovascular events by causing endothelial dysfunction; $755,760 (Jul 2009 to Oct 2012)

  • General research fund, RGC: Nimodipine suppresses chemokine release via inhibition of adenosine uptake in endothelial cells; $954,000 (Dec 2007 to May 2010)

My Collaborators

  • Prof. Y.W. Kwan, Department of Pharmacology, The Chinese University of Hong Kong, Hong Kong
  • Prof. Simon M.Y. Lee and Dr. Maggie PM Hoi, Institute of Chinese Medical Sciences, University of Macau , Macau
  • Dr. Chung-Ming Tse, Division of Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
  • Dr YB Zhang, School of Chinese Medicine, The University of Hong Kong

Office:

2/F, 21 Sassoon Road, Li Ka Shing Faculty of Medicine, Laboratory Block, Faculty of Medicine Building, Hong Kong SAR, China.