Our contribution to the prevention and treatment of COVID-19

 

As healthcare professionals, pharmacists play a key role in the pandemic. Our department has significant contribution to the education, practice and research in COVID-19 and vaccine.

 

Central Dilution Training Online Training for the Reconstitution_banner_4_reg
Education in Vaccination

To facilitate the operation of vaccination programme and the education of current and future pharmacists in Hong Kong, our department has partnered with other professional institutes and organisations to provide various vaccination training programmes.

 

Vaccine injection
The programs

 

Online Training Programme for the Reconstitution of Fosun/BioNTech COVID-19 Vaccine Programme

 

Immunisation Training Programme for Registered Pharmacists

 

  

Immunisation Training Programme for Registered Pharmacists


 

Immunisation Workshop for BPharm Students 

 

 

  

Immunisation Training Programme for Undergraduate Students


Photos
Immunisation Training Programme

Immunisation Training Programme


Immunisation Workshop for BPharm Students

Immunisation Workshop for BPharm Students



Practice in Vaccination Centre

HKUMed is responsible for the Community Vaccination Centre at Ap Lei Chau Sports Centre (ALC CVC). Pharmacists from our department and our alumni help to prepare and dilute the vaccines on site.

 

CVC Center
The ALC CVC

The Community Vaccination Centre at Ap Lei Chau Sports Centre (ALC CVC)

 

  

The Community Vaccination Centre at Ap Lei Chau Sports Centre


Photos
ALC CVC Center

ALC CVC Center


The HKU Pharmacist Team

The HKU Pharmacist Team


Vaccination Booths

Vaccination Booths


Preparation Area

Preparation Area



Research related to COVID-19 and Vaccine

Our department is actively involved in research with COVID-19 and vaccines. We have a number of projects funded by the government to improve our understanding of the disease and the impact of the new vaccines, and the development of new medication to fight against the virus.

 

Research for COVID-19
Projects

COVID-19 Vaccines Adverse Effects Response & Evaluation (CARE) 

Care Program

Click to watch


A multinational big data Covid-19 Epidemiological Study on post infection Outcomes (ACESO)

  • This is a multinational study with collaborations from USA, Australia, UK, Taiwan, Korea, Finland and Netherlands to investigate the long-term outcomes of COVID-19 on individual patient as well as on population as a whole. 
    Principal Investigator: Professor Ian Wong, Funding: HK$9,691,060


Effectiveness of single and combined anti-COVID-19 drugs among hospitalized COVID-19 patients in Hong Kong

  • The objective of this study is to evaluate the effectiveness of single and combined antiviral therapies in treating hospitalized patients confirmed with COVID-19 infection in Hong Kong, measure potential effects of adjunctive drugs, and assess post-discharge adverse events among COVID-19 patients. 
    Principal Investigator: Dr. Carlos Wong, Funding: HK$482,960


The role of smoking on the regulation of ACE2-mediated infectability of COVID-19

  • The broad goal of this research is to exploit how the expression of angiotensin-converting enzyme 2 (ACE2) is regulated in airway epithelia under smoking in vitro and in vivo before and after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Emphasis will be placed on its roles in viral replication and renin-angiotensin system (RAS) in relation to disease severity. 
    Principal Investigator: Dr. Judith Mak, Funding: HK$1,997,000


Photos
CARE Programme

CARE Programme


New Medication Development

New Medication Development


Our Researcher

Our Researcher


Big Data Research

Big Data Research



Knowledge Exchange related to COVID-19 and Vaccine
 
Knowledge Exchange
Media

  • 明報 - 副刊健康版 [疫苗有空氣會攞命? 肌肉注射 不會氣泡栓塞] | View

新冠疫苗上月開打,大家捲起衫袖露出上臂接種。港大微生物學系講座教授袁國勇卻自行在前臂打針,還說:「呢個皮內注射,好痛㗎,不過正嘢嚟。」疫苗接種方式一般分為肌肉、皮下、皮內注射3種,究竟有何分別?

  • 香港電台香港家書 [新冠疫苗副作用受嚴謹機制監察] | View

香港大學藥理及藥劑學系系主任黃志基

  • 冠狀病毒病疫苗安全監測計劃 CARE Programme | View

2019 冠狀病毒病是影響人們健康和生活的全球大流行的病毒。2019冠狀病毒病疫苗預計將在控制全球大流行中發揮重要作用。因此,在香港市民開始接種2019冠狀病毒病疫苗的同時,密切監測疫苗的安全性至關重要。全面的疫苗上巿後監測機制可以觀察到疫苗廣泛使用後的潛在異常事件。 香港大學2019冠狀病毒病疫苗安全監測計劃(CARE)是一套完善的2019冠狀病毒病疫苗安全監測機制,嚴密監測各類2019冠狀病毒疫苗已知及潛在的的異常事件,確定所有異常事件的詳細信息,並將這一監測結果及時向社會公眾公佈。此監測計劃是由香港大學藥理及藥劑學系團隊負責實行。 研究團隊誠邀首批優先接種2019冠狀病毒病疫苗的人士積極參與研究計劃, 協助研究團隊吸取經驗, 推展日後疫苗接種, 齊心打贏抗疫戰。


Publications related to COVID-19 and Vaccine

2022

  • mRNA (BNT162b2) COVID-19 vaccination increased risk of Bell’s palsy: a nested case control and self-controlled case series study | View

Eric Yuk Fai Wan, Celine Sze Ling Chui, Vanessa Wai Sei Ng, Yuan Wang, Vincent Ka Chun Yan, Ivan Chun, Hang Lam, Min Fan, Francisco Tsz Tsun Lai, Esther Wai Yin Chan, Xue Li, Carlos King Ho Wong, Raccoon Ka Cheong Chung, Benjamin John Cowling, Wing Chi Fong, Alexander Yuk Lun Lau, Vincent, Chung Tong Mok, Frank Ling Fung Chan, Cheuk Kwong Lee, Lot Sze Tao Chan, Dawin Lo, Kui Kai Lau, Ivan, Fan Ngai Hung, Chak Sing Lau, Gabriel Matthew Leung, Ian Chi Kei Wong. mRNA (BNT162b2) COVID-19 vaccination increased risk of Bell’s palsy: a nested case control and self-controlled case series study. Clinical Infectious Diseases. 2022/06/08. DOI:http://doi.org/10.1093/cid/ciac460
Impact factor: 9.079

  • Safety of two-dose COVID-19 vaccination (BNT162b2 and CoronaVac) in adults with cancer: a territory-wide cohort study | View

Wei Kang, Jessica J. P. Shami, Vincent K. C. Yan, Xuxiao Ye, Joseph E. Blais, Xue Li, Victor H. F. Lee, Celine S. L. Chui, Francisco T. T. Lai, Eric Y. F. Wan, Carlos K. H. Wong, Ian C. K. Wong, Esther W. Chan. Safety of two-dose COVID-19 vaccination (BNT162b2 and CoronaVac) in adults with cancer: a territory-wide cohort study. Journal of Hematology & Oncology. 2022/05/19. DOI: https://doi.org/10.1186/s13045-022-01265-9
Impact factor: 17.388

  • COVID-19 Vaccination Preferences of University Students and Staff in Hong Kong

Lydia WY Fung*, Jiaxi Zhao*, Vincent KC Yan, Joseph E Blais, Jacky CH Chan, Silvia TH Li, Jessica JP Shami, Christine Kwan, Yue Wei, Carlos KH Wong, Xue Li, Celine SL Chui, Eric YF Wan, Francisco TT Lai, Samson Tse, Benjamin J Cowling, Ian CK Wong, Esther W Chan. JAMA Network Open. (Accepted. To be published in May.)
Impact Factor: 8.485

  • Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: A descriptive cohort study among 1.1 million vaccinated people in Hong Kong | View

Xue Li, Le Gao, Xinning Tong, Vivien K.Y. Chan, Celine S.L. Chui, Francisco T.T. Lai, Carlos K.H. Wong, Eric Y.F. Wan, Esther W.Y. Chan, Kui Kai Lau, Chak Sing Lau, Ian C.K. Wong. Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: A descriptive cohort study among 1.1 million vaccinated people in Hong Kong. Journal of Autoimmunity. 2022/04/14. DOI: https://doi.org/10.1016/j.jaut.2022.102830
Impact Factor: 7.094

  • Safety of inactivated and mRNA COVID-19 vaccination among patients treated for hypothyroidism: a population-based cohort study | View

Xi Xiong, Carlos King Ho Wong, Ivan Chi Ho Au, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Celine Sze Ling Chui, Esther Wai Yin Chan, Franco Wing Tak Cheng, Kristy Tsz Kwan Lau, Chi Ho Lee, Yu-Cho Woo, David Lui, Ian Chi Kei Wong. Safety of inactivated and mRNA COVID-19 vaccination among patients treated for hypothyroidism: a population-based cohort study. Thyroid. 2022/04/07. DOI: https://doi.org/10.1089/thy.2021.0684
Impact Factor: 6.568

  • Adverse Events of Special Interest Following the Use of BNT162b2 in Adolescents: A Population-Based Retrospective Cohort Study | View

Francisco Tsz Tsun Lai, Gilbert T Chua, Edward Wai Wa Chan, Lei Huang, Mike Yat Wah Kwan, Tiantian Ma, Xiwen Qi, Celine Sze Ling Chui, Xue Li, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, Ian Chi Kei Wong, Patrick Ip. Adverse Events of Special Interest Following the Use of BNT162b2 in Adolescents: A Population-Based Retrospective Cohort Study. Emerging Microbes & Infections. 2022/03/21. DOI: https://doi.org/10.1080/22221751.2022.2050952
Impact Factor: 7.163

  • Impact of a delayed second dose of mRNA vaccine (BNT162b2) and inactivated SARS-CoV-2 vaccine (CoronaVac) on risks of all-cause mortality, emergency department visit, and unscheduled hospitalization | View

Carlos King Ho Wong, Xi Xiong, Kristy Tsz Kwan Lau, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Esther Wai Yin Chan, Eric Yuk Fai Wan, Ivan Chi Ho Au, Benjamin John Cowling, Cheuk Kwong Lee, Ian Chi Kei Wong. Impact of a delayed second dose of mRNA vaccine (BNT162b2) and inactivated SARS-CoV-2 vaccine (CoronaVac) on risks of all-cause mortality, emergency department visit, and unscheduled hospitalization. BMC Medicine. 2022/03/17. DOI: https://doi.org/10.1186/s12916-022-02321-4
Impact Factor: 8.775

  • Myocarditis Following COVID-19 BNT162b2 Vaccination Among Adolescents in Hong Kong | View

Xue Li, Francisco Tsz Tsun Lai, Gilbert T. Chua, Mike Yat Wah Kwan, Yu Lung Lau, Patrick Ip, Ian Chi Kei Wong. Myocarditis Following COVID-19 BNT162b2 Vaccination Among Adolescents in Hong Kong. JAMA Pediatrics. 2022/02/25. DOI: http://doi.org/10.1001/jamapediatrics.2022.0101
Impact Factor: 16.193

  • Lack of inflammatory bowel disease flare-up following two-dose BNT162b2 vaccine: a population-based cohort study | View

Xue Li, Xinning Tong, Ian Chi Kei Wong, Kuan Peng, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Eric Yuk Fai Wan, Carlos King Ho Wong, Wai Keung Leung, Esther Wai Yin Chan. Lack of inflammatory bowel disease flare-up following two-dose BNT162b2 vaccine: a population-based cohort study. Gut. 2022/02/08. DOI: http://doi.org/10.1136/gutjnl-2021-326860
Impact Factor: 23.059

  • Self-reported reactogenicity of CoronaVac (Sinovac) compared with Comirnaty (Pfizer-BioNTech): a prospective cohort study with intensive monitoring | View

Francisco Tsz Tsun Lai, Miriam Tim Yin Leung, Edward Wai Wa Chan, Lei Huang, Lauren Ka Wun Lau, Kuan Peng, Janice Ching Nam Leung, Min Fan, Kailin Chen, Dawn Hei Lum, Xue Li, Celine Sze Ling Chui, Eric Yuk Fai Wan, Carlos King Ho Wong, Edwin Fung Shing Lam, Terence Yung Yan Cheung, Benjamin John Cowling, Ian Chi Kei Wong, Esther Wai Yin Chan. Self-reported reactogenicity of CoronaVac (Sinovac) compared with Comirnaty (Pfizer-BioNTech): A prospective cohort study with intensive monitoring. Vaccine. 2022 Feb 7. DOI: https://doi.org/10.1016/j.vaccine.2022.01.062
Impact factor: 3.641

  • Herpes zoster related hospitalisation after inactivated (CoronaVac) and mRNA (BNT162b2) SARS-CoV-2 vaccination: a self-controlled case series and nested case-control study | View

Eric Yuk Fai Wan, Celine Sze Ling Chui, Yuan Wang, Vanessa Wai Sei Ng, Vincent Ka Chun Yan, Francisco Tsz Tsun Lai, Xue Li, Carlos King Ho Wong, Esther Wai Yin Chan, Christina Sze Man Wong, Kathy Sze Man Leung, Michael Yuxuan Ni, Sophie Alessandra Valkenburg, Joseph Sriyal Malik Peiris, Joseph Tsz Kei Wu, Benjamin John Cowling, Darren M Ashcroft, Ivan Fan Ngai Hung, Gabriel Matthew Leung, Ian Chi Kei Wong. Herpes zoster related hospitalization after inactivated (CoronaVac) and mRNA (BNT162b2) SARS-CoV-2 vaccination: A self-controlled case series and nested case-control study. The Lancet Regional Health – Western Pacific. 2022 Feb 1. DIO: https://doi.org/10.1016/j.lanwpc.2022.100393

  • COVID-19 vaccines and risks of hematological abnormalities: nested case-control and self-controlled case series study | View

Chor-Wing Sing, Casey Tse Lam Tang, Celine Sze Ling Chui, Min Fan, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, Ivan Fan Ngai Hung, Anskar Yu-Hung Leung, Ching-Lung Cheung, Ian Chi Kei Wong. COVID-19 vaccines and risks of hematological abnormalities: nested case-control and self-controlled case series study. American Journal of Hematology. 2022 Jan 26. DOI: https://doi.org/10.1002/ajh.26478
Impact factor: 10.047

  • Carditis following Covid-19 vaccination with messenger RNA vaccine (BNT162b2) and inactivated virus vaccine (CoronaVac): a nested case-control study | View

Francisco Tsz Tsun Lai, Xue Li, Kuan Peng, Lei Huang, Patrick Ip, Xinning Tong, Celine Sze Ling Chui, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, David Chung Wah Siu, Ian Chi Kei Wong. Carditis After COVID-19 Vaccination With a Messenger RNA Vaccine and an Inactivated Virus Vaccine. Annals of Internal Medicine. 2022 Jan 25. DOI: https://doi.org/10.7326/M21-3700
Impact Factor: 25.391

  • Examining family pre-pandemic influences on adolescent psychosocial wellbeing during the COVID-19 pandemic | View

Wong R.S.M., Tung T.S., Li X., Chui S.L.C., Tso W.Y.W., Lee T.M.C., Chan K.L., Wing Y.K., Fu K.W., Wong I.C.K. and Ip P., Examining family pre-pandemic influences on adolescent psychosocial wellbeing during the COVID-19 pandemic, Current Psychology. 2022 Jan 22. DOI: http://doi.org/10.1007/s12144-022-02736-5
Impact factor: 4.297

  • Multimorbidity and adverse events of special interest associated with Covid-19 vaccines in Hong Kong | View

Francisco Tsz Tsun Lai, Lei Huang, Celine Sze Ling Chui, Eric Yuk Fai Wan, Xue Li, Carlos King Ho Wong, Edward Wai Wa Chan, Tiantian Ma, Dawn Hei Lum, Janice Ching Nam Leung, Hao Luo, Esther Wai Yin Chan, Ian Chi Kei Wong. Multimorbidity and adverse events of special interest associated with Covid-19 vaccines in Hong Kong. Nature Communications. 2022 Jan 20. DOI: https://doi.org/10.1038/s41467-022-28068-3
Impact factor: 14.919

  • Post-Covid-19-vaccination adverse events and healthcare utilization among individuals with or without previous SARS-CoV-2 infection | View

Francisco Tsz Tsun Lai, Lei Huang, Kuan Peng, Xue Li, Celine Sze Ling Chui, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, Ivan Fan Ngai Hung, Ian Chi Kei Wong. Post-Covid-19-vaccination adverse events and healthcare utilization among individuals with or without previous SARS-CoV-2 infection. Journal of Internal Medicine. 2022Jan 19. DOI :https://doi.org/10.1111/joim.13453
Impact Factor: 8.989

  • Mental health & maltreatment risk of children with special educational needs during COVID-19 | View

Tso W.Y.W., Chan K.L., Lee T.M.C., Rao N., Lee S.L., Jiang F., Chan H.S.S., Wong W.H.S., Wong R.S.M., Tung T.S., Yam J.C., Liu A.P.Y., Chua G.T., Sou Da Rosa Duque J., Lam L.N.A., Yip K.M., Leung L.K., Wang Y., Sun J., Wang G., Chan G.C.F., Wong I.C.K. and Ip P., Mental health & maltreatment risk of children with special educational needs during COVID-19, Child Abuse & Neglect. 2022 Jan 10. DOI: http://doi.org/10.1016/j.chiabu.2021.105457
Impact factor: 3.928

  • Bell's Palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study | View

Eric YF Wan*, Celine SL Chui*, Francisco TT Lai, Esther WY Chan, Xue Li, Vincent KC Yan, Le Gao, Qiuyan Yu, Ivan CH Lam, Raccoon KC Chung, Benjamin J Cowling, WC Fong, Alexander YL Lau, Vincent CT Mok, Frank LF Chan, CK Lee, Lot ST Chan, Dawin Lo, KK Lau, Ivan FN Hung, Gabriel M Leung, Ian CK Wong* († Co- first author *Corresponding author). The Lancet Infectious Diseases. 22(1): 64-72. 2022 Jan 1. Published online 2021 Aug 16. DOI: https://doi.org/10.1016/S1473-3099(21)00451-5.
Impact factor: 25.071

2021

  • Comparing self-reported reactogenicity between adolescents and adults following the use of BNT162b2 (Pfizer-BioNTech) messenger RNA Covid-19 vaccine: a prospective cohort study | View

Edward Wai Wa Chan, Miriam Tim Yin Leung, Lauren Ka Wun Lau, Janice Leung, Dawn Lum, Rosa Sze-Man Wong, Xue Li, Celine Sze Ling Chui, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, Patrick Ip, Ian Chi Kei Wong, Francisco Tsz Tsun Lai. Comparing self-reported reactogenicity between adolescents and adults following the use of BNT162b2 (Pfizer-BioNTech) messenger RNA COVID-19 vaccine: a prospective cohort study. International Journal of Infectious Diseases. 2021 Dec 26. DOI: https://doi.org/10.1016/j.ijid.2021.12.354
Impact factor: 3.623

  • Use of DPP4i reduced odds of clinical deterioration and hyperinflammatory syndrome in COVID-19 patients with type 2 diabetes: Propensity score analysis of a territory-wide cohort in Hong Kong | View

Wong CKH, Lui DTW, Lui AYC, Kwok ACY, Low MCH, Lau KTK, et al. Diabetes & Metabolism. 2021 Dec 1.48(1):101307. DOI: https://doi.org/10.1016/j.diabet.2021.101307.
Impact factor: 6.041

  • Epidemiology of acute Myocarditis/Pericarditis in Hong Kong adolescents following Comirnaty vaccination. | View

Chua GT, Kwan MYW, Chui CSL, Smith RD, Cheung EC, Tian T, Leung MTY, Tsao SSL, Kan E, Ng WKC, Man Chan VC, Tai SM, Yu TC, Lee KP, Wong JSC, Lin YK, Shek CC, Leung ASY, Chow CK, Li KW, Ma J, Fung WY, Lee D, Ng MY, Wong WHS, Tsang HW, Kwok J, Leung D, Chung KL, Chow CB, Chan GCF, Leung WH, To KKW, Yuen KY, Lau YL, Wong ICK, Ip P. Clinical Infectious Diseases. 2021 Nov 28: ciab989. doi: 10.1093/cid/ciab989.
Impact factor: 9.079

  • COVID-19 vaccine preferences among university students in Hong Kong: A discrete choice experiment. | View

Li X, Chong MY, Chan CY, Chan VWS, Tong X. BMC Research Notes. 2021 Nov 22;14(1):421. doi: 10.1186/s13104-021-05841-z. PMID: 34809681; PMCID: PMC8607213. 

  • Adverse event reporting and Bell's palsy risk after COVID-19 vaccination - Authors' reply | View

Ian Chi Kei Wong, Eric Yuk Fai Wan, Celine Sze Ling Chui, Xue Li, Esther Wai Yin Chan. Adverse event reporting and Bell's palsy risk after COVID-19 vaccination – Authors' reply. The Lancet Infectious Diseases. 2021 Nov 1. DOI: https://doi.org/10.1016/S1473-3099(21)00631-9
Impact factor: 25.071

  • Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: A descriptive cohort study among 1.1 million vaccinated people in Hong Kong. | View

Xue Li, Le Gao, Xinning Tong, Vivien K.Y. Chan, Celine S.L. Chui, Francisco Lai, Carlos Wong, Eric Y.F. Wan, Esther W.Y. Chan, Kui Kai Lau, Chak Sing Lau, Ian C.K. Wong. medRxiv. 2021 Oct 23. doi: https://doi.org/10.1101/2021.10.21.21265314

  • Disrupted daily routines mediate the socioeconomic gradient of depression amid public health crises: A repeated cross-sectional study. | View

Lai FTT, Chan VKY, Li TW, Li X, Hobfoll SE, Lee TMC, Hou WK. Australian & New Zealand Journal of Psychiatry. 2021 Oct 22.
Impact factor: 5.744

  • Two-dose Covid-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong. Annals of the Rheumatic Diseases. | View

Xue Li, Xinning Tong, Winnie Wan Yin Yeung, Peng Kuan, Samson Hin Hei Yum, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, Chak Sing Lau, Ian Chi Kei Wong. Annals of the Rheumatic Diseases. 2021 Oct 21. DOI: http://doi.org/10.1136/annrheumdis-2021-221571
Impact factor: 19.103

  • Loneliness, depression, anxiety, and post-traumatic stress disorder among Chinese adults during COVID-19: A cross-sectional online survey. | View

Zijun Xu,Dexing Zhang ,Dong Xu, Xue Li, Yao Jie Xie, Wen Sun, Eric Kam-pui Lee, Benjamin Hon-kei Yip, Shuiyuan Xiao, Samuel Yueng-shan Wong. PLoS One. 2021 Oct 21; 16(10): e0259012. DOI: 10.1371/journal.pone.0259012.
Impact factor: 3.240

  • Impact of varying wave periods of COVID-19 on in-hospital mortality and length of stay for admission through emergency department: A territory-wide observational cohort study. | View

Xi Xiong, Abraham K. C. Wai, Janet Y. H. Wong, Eric H. M. Tang, Owen C. K. Chu, Carlos K. H. Wong, Timothy H. Rainer. Influenza and Other Respiratory Viruses. 2021 Oct 13;10.1111/irv.12919. doi: 10.1111/irv.12919.
Impact factor: 4.380

  • Changes in emergency department visits, diagnostic groups and 28-day mortality associated with the COVID-19 pandemic: a territory-wide, retrospective, cohort study. | View

Abraham K.C. Wai, MBChB, FHKAM∗, Carlos K.H. Wong, PhD∗, Janet Y.H. Wong, RN, PhD, Xi Xiong, Msc (Hons), Owen C.K. Chu, BSc (Hons), Man Sing Wong, PhD, Matthew S.H. Tsui, MBBS, FHKAM, Timothy H. Rainer, MD, FHKAM. Annuals of Emergency Medicine: An international Journal. (Available online 2021 Sept 24). DOI: https://doi.org/10.1016/j.annemergmed.2021.09.424.
Impact factor: 5.721
*contributed equally as co-first author

  • Optimal timing of remdesivir initiation in hospitalized COVID-19 patients administered with dexamethasone. | View

Carlos K H Wong, PhD, Kristy T K Lau, MSc, Ivan C H Au, BSc, Xi Xiong, MSc, Matthew S H Chung, BSc, Eric H Y Lau, PhD, Benjamin J Cowling, PhD. Clinical Infectious Diseases. 2021 Aug 22;ciab728. doi: 10.1093/cid/ciab728.
Impact factor: 9.079 

  • Clinical improvement, outcomes, antiviral activity, and costs associated with early treatment with remdesivir for patients with COVID-19. | View

Carlos K H Wong, PhD, Kristy T K Lau, MSc, Ivan C H Au, BSc, Xi Xiong, MSc, Eric H Y Lau, PhD, Benjamin J Cowling, PhD. Clinical Infectious Diseases. 2021 July 15. 
Impact factor: 9.079

  • Clinical Characteristics and Transmission of COVID-19 in Children and Youths During 3 Waves of Outbreaks in Hong Kong. | View

Chua GT, Wong JSC, Lam I, Ho PPK, Chan WH, Yau FYS, Rosa Duque JS, Ho ACC, Siu KK, Cheung TWY, Lam DSY, Chan VCM, Lee KP, Tsui KW, Wong TW, Yau MM, Yau TY, Chan KCC, Yu MWL, Chow CK, Chiu WK, Chan KC, Wong WHS, Ho MHK, Tso WWY, Tung KTS, Wong CS, Kwok J, Leung WH, Yam JC, Wong ICK, Tam PKH, Chan GCF, Chow CB, To KKW, Lau YL, Yuen KY, Ip P, Kwan MYW. JAMA Network Open. 2021 May 3;4(5): e218824. doi: 10.1001/jamanetworkopen.2021.8824. (PMID: 33938934).
Impact factor: 8.485

  • Global changes to the chemotherapy service during the covid-19 pandemic. | View

Chow MC, Chambers P, Singleton G, Patel J, Cooper S, Mythen C, Bautista-González E, Chisnall G, Djellouli N, Thwaites B, Wong IC, Vindrola-Padros C. Journal of Oncology Pharmacy Practice. 2021 Jul;27(5):1073-1079. doi: 10.1177/10781552211015767. Online ahead of print. (PMID: 33983080).  
Impact factor: 1.809

  • Impact of COVID-19 pandemic on serum vitamin D level among infants and toddlers: An interrupted time series analysis and before-and-after comparison. | View

Wong, RS, Tung, KTS, So, HK, Wong, WHS, Wong, SY, Tsang, HW, Tung, JYL, Chua, GT, Ho, MHK Wong, ICK, Ip, P. Nutrients. 2021 Apr 13;13(4):1270. doi: 10.3390/nu13041270.
Impact factor: 5.719

  • Development of a multivariable prediction model for severe COVID-19 disease: A population-based study from Hong Kong. | View

Zhou J, Lee S, Wang X, Li Y, Wu WKK, Liu T, Cao Z, Zeng DD, Leung KSK, Wai AKC, Wong ICK, Cheung BMY, Zhang Q, Tse G. NPJ Digit Medicine. 2021 Apr 8;4(1):66. doi: 10.1038/s41746-021-00433-4. (PMID: 33833388). 
Impact factor: 11.653

  • Physical and mental health outcomes including behavior and attitudes in people having social contacts with COVID-19 patients. | View

Xu ZJ, Zhang DX, Xu D, Li X, Xie YJ, Sun W, Lee EKP, Yip BHK, Mo PKH, Xiao SY, Wong SYS. PLoS One. 2021 Feb 2;16(2): e0245945. doi: 10.1371/journal.pone.0245945. (PMID: 33529204). 
Impact factor: 3.240

  • Saliva viral load better correlates with clinical and immunological profiles in children with coronavirus disease 2019 | View

Chua GT, Wong JSC, To KKW, Lam ICS, Yau FYS, Chan WH, Ho PPK, Duque JSR, Yip CCY, Ng ACK, Wong WHS, Kwong JHY, Leung KFS, Wan PT, Lam K, Wong ICK, Kwok J, Ho MHK, Chan GCF, Lau YL, Ip P, Kwan MYW. Emerging Microbes & Infections. 2021 Dec; 10(1):235-241. doi: 10.1080/22221751.2021.1878937. (PMID: 33467982). 
Impact factor: 7.163 

  • Interaction effects between angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and steroid or antiviral therapies in COVID-19: A population-based study | View

Zhou J, Tse G, Lee S, Liu T, Cao Z, Zeng DD, Leung KSK, Wai AKC, Wong ICK, Cheung BMY, Zhang Q. Journal of Medical Virology. 2021 May;93(5):2635-2641. doi: 10.1002/jmv.26904. Epub 2021 Mar 9.
Impact factor: 2.327

  • COVID-19 and health-related quality of life: A community-based online survey in Hong Kong. | View

Edmond PH Choi, Bryant PH Hui, Eric YF Wan, Jojo YY Kwok, Tiffany HL Tam, Chanchan Wu. International Journal of Environmental Research and Public Health. 2021 Mar 20; 18(6): 3228. doi: 10.3390/ijerph18063228. (PMID: 33804725).
Impact factor: 3.390

  • Clinical outcomes of different therapeutic options for COVID-19 in two Chinese case cohorts: A propensity-score analysis. | View

Wong CKH, Wan EYF, Luo S, Ding Y, Lau EHY, Ling P, Hu X, Lau ECH, Wong J, Zheng X, Cowling BJ, Weng J, Leung GM. EClinicalMedicine. 2021 Feb; 32:100743. doi: 10.1016/j.eclinm.2021.100743. Epub 2021 Feb 13. (PMID: 33615206)

  • Cardiovascular sequalae in uncomplicated COVID-19 survivors. | View

Zhou M, Wong CK, Un KC, Lau YM, Lee JC, Tam FC, Lau YM, Lai WH, Tam AR, Lam YY, Pang P, Tong T, Tang M, Tse HF, Ho D, Ng MY, Chan EW, Wong ICK, Lau CP, Hung IF, Siu CW. PLoS One. 2021 Feb 11;16(2): e0246732. doi: 10.1371/journal.pone.0246732. eCollection 2021. (PMID: 33571321).
Impact factor: 3.240

  • Comparative study of the clinical characteristics and epidemiological trend of 244 COVID-19 infected children with or without GI symptoms. | View

Xiong XL, Wong KK, Chi SQ, Zhou AF, Tang JQ, Zhou LS, Chung PH, Chua G, Tung K, Wong I, Chui C, Li X, Kwan MY, Wong WH, Ho MH, Chan GC, Cao GQ, Li K, Ip P, Chen P, Tang ST, Tam PK. Gut. 2021 Feb;70(2):436-438 (PMID: 32430348). DOI: 10.1136/gutjnl-2020-321486.
Impact factor: 23.059

2020

  • Development and validation of risk prediction models for COVID-19 positivity in a hospital setting. | View

MY Ng, Eric YF Wan, Frank HY Wong, ST Leung, Jonan CY Lee, Thomas WY Chin, Christine SY Lo et al. International Journal of Infectious Diseases. 101(2020) 74-82; doi: 10.1016/j.ijid.2020.09.022 (PMID: 32947055)

  • Orodispersible and transmucosal alternative medications for symptom control in adults | View

Sutherland AE, Presland M, Harrop E, Carey M, Miller M, Wong ICKC. BMJ Supportive and Palliative Care. 2020;0: 1-11. doi: 10.1136/bmjspcare-2020-002784. Online ahead of print. (PMID: 33262121)

  • COVID-19 in children across three Asian cosmopolitan regions. | View

Chua GT, Xiong X, Choi EH, Han MS, Chang SH, Jin BL, Lee EJ, Kim BN, Kim MK, Doo K, Seo JH, Kim YJ, Kim YJ, Park JY, Suh SB, Lee H, Cho EY, Kim DH, Kim JM, Kim HY, Park SE, Lee JK, Jo DS, Cho SM, Choi JH, Jo KJ, Choe YJ, Kim KH, Chi S, Tang ST, Qin H, Zhou LS, Chen P, Wong JSC, Chan KCC, Yau FYS, Lam SY, Chow CCK, Wong TW, Chan VC, Poon GWK, Chow CB, Wong WHS, Lau YL, Chan GCF, Chui CSL, Li X, Ho MHK, Wong ICK, Tam PKH, To KKW, Kim JH, Ip P, Kwan MYW. Emerg Microbes Infect. 2020 Dec;9(1):2588-2596. doi: 10.1080/22221751.2020.1846462. (PMID: 33138739)

  • Short- and potential long-term adverse health outcomes of COVID-19: A rapid review. | View

Leung TYM, Chan AYL, Chan EW, Chan VKY, Chui CSL, Cowling BJ, Gao L, Ge MQ, Hung IFN, Ip MSM, Ip P, Lau KK, Lau CS, Lau LKW, Leung WK, Li X, Luo H, Man KKC, Ng VWS, Siu CW, Wan EYF, Wing YK, Wong CSM, Wong KHT, Wong ICK. Emerg Microbes Infect. 2020 Dec;9(1):2190-2199. doi: 10.1080/22221751.2020.1825914. (PMID: 32940572)

  • Vulnerability and resilience in children during the COVID-19 pandemic. | View

Tso WWY, Wong RS, Tung KTS, Rao N, Fu KW, Yam JCS, Chua GT, Chen EYH, Lee TMC, Chan SKW, Wong WHS, Xiong X, Chui CS, Li X, Wong K, Leung C, Tsang SKM, Chan GCF, Tam PKH, Chan KL, Kwan MYW, Ho MHK, Chow CB, Wong ICK, Lp P. Eur Child Adolesc Psychiatry. 2020 Nov 17:1-16. doi: 10.1007/s00787-020-01680-8. Online ahead of print. (PMID: 33205284)

  • Frequency and Distribution of Chest Radiographic Findings in COVID-19 Positive Patients. | View

HY Wong, HY Lam, AH Fong, ST Leung, TW Chin, CS Lo, MM Liu, JC Lee, KW Chiu T Chung, EY Lee, Eric YF Wan, Ivan FN Hung, Tina PW Lam, MY Ng. Radiology. 2020 Aug; 296(2): E72-E78; doi: 10.1148/radiol.2020201160 (PMID: 32216717)

  • False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease. I View

To KK, Chua GT, Kwok KL, Wong JS, Au DCY, Lam YY, Wong WH, Ho MH, Chan GC, Chui CS, Li X, Tung KT, Wong RS, Tso WW, Wong IC, Wong CS, Fong CH, Chan KH, Yuen KY, Ip P, Kwan MY. Diagn Microbiol Infect Dis. 2020 Nov; 98(3):115141. doi: 10.1016/j.diagmicrobio.2020.115141. Epub 2020 Jul 17. (PMID: 32795776) /p>

  • Clinical presentations, laboratory and radiological findings, and treatments for 11,028 COVID-19 patients: A systematic review and meta-analysis. | View

Wong CKH, Wong JYH, Tang EHM, Au CH, Wai AKC. Scientific Reports. 2020 Nov 13;10(1):19765. doi: 10.1038/s41598-020-74988-9. (PMID: 33188232)

  • Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic. | View

Lam JKW, Cheung CCK, Chow MYT, Harrop E, Lapwood S, Barclay SIG, Wong ICK. Adv Drug Deliv Rev. 2020; 160:234-243. doi: 10.1016/j.addr.2020.10.018. Epub 2020 Nov 1. (PMID: 33137363)

  • Haematological and immunological data of Chinese children infected with coronavirus disease 2019. | View

Xiong X, Chua GT, Chi S, Kwan MYW, Wong WHS, Zhou A, Shek CC, Tung KTS, Qin H, Wong RS, Li X, Chen P, Li S, Chui CS, Tso WWY, Ho MHK, Wong ICK, Chan GCF, Lau YL, Wong KKY, Chung PHY, Li H, Tam PKH, Tang ST, Lp P. Data Brief. 2020 Jun 30;31:105953. doi: 10.1016/j.dib.2020.105953. eCollection 2020 Aug. (PMID: 32685628)

  • Long-term outcome of short-course high-dose glucocorticoids for SARS: a 17-year follow-up in SARS survivors. | View

Sing CW, Tan KCB, Wong ICK, Cheung BMY, Cheung CL. Clinical Infectious Diseases. 2020 Jul 16: ciaa992. doi: 10.1093/cid/ciaa992. Online ahead of print. (PMID: 32671407)

  • Impact of National Containment Measures on Decelerating the Increase in Daily New Cases of COVID-19 in 54 Countries and 4 Epicenters of the Pandemic: Comparative Observational Study. | View

Wong CKH, Wong JYH, Tang EHM, Au CH, Lau KTK, Wai AKC. J Med Internet Res. 2020 Jul 22;22(7): e19904. doi: 10.2196/19904. (PMID: 32658858) /p>

  • How are family doctors serving the Hong Kong community during the COVID-19 outbreak? A survey of HKCFP members. | View

Esther YT Yu, Will LH Leung, Samuel YS Wong, Kiki SN Liu, Eric YF Wan for the HKCFP Executive and Research Committee. Hong Kong Medical Journal. 2020: 26(3), 176-83; doi: 10.12809/hkmj208606 (PMID: 32475841)

  • Coronavirus disease 2019 (COVID-19): Latest developments in potential treatments. | View

Hon KL, Leung KKY, Leung AK, Qian SY, Chan VP, Ip P, Wong IC. Drugs Context. 2020 Jun 29;9:2020-4-15. doi: 10.7573/dic.2020-4-15. eCollection 2020. (PMID: 32655654)

  • A Comparison between Chinese children infected with Coronavirus Disease-2019 and with severe acute respiratory syndrome 2003. | View

Xiong X, Chua GT, Chi S, Kwan MYW, Sang Wong WH, Zhou A, Shek CC, Tung KTS, Qin H, Wong RS, Li X, Chen P, Li S, Chui CS, Tso WWY, Ho MHK, Wong ICK, Chan GCF, Lau YL, Wong KKY, Chung PHY, Li H, Tam PKH, Tang ST, Ip P. J Pediatr. 2020 Sep;224:30-36. doi: 10.1016/j.jpeds.2020.06.041. Epub 2020 Jun 18. (PMID: 32565097)

  • Depression and anxiety in Hong Kong during COVID-19. | View

Edmond PH Choi, Bryant PH HUI, Eric YF Wan. International Journal of Environmental Research and Public Health. 2020; 17(10), 3740; doi: 10.3390/ijerph17103740 (PMID: 32466251)

  • ADHD management during the COVID-19 pandemic: Guidance from the European ADHD Guidelines Group. | View

Cortese S, Asherson P, Sonuga-Barke E, Banaschewski T, Brandeis D, Buitelaar J, Coghill D, Daley D, Danckaerts M, Dittmann RW, Doepfner M, Ferrin M, Hollis C, Holtmann M, Konofal E, Lecendreux M, Santosh P, Rothenberger A, Soutullo C, Steinhausen HC, Taylor E, Van der Oord S, Wong I, Zuddas A, Simonoff E; European ADHD Guidelines Group. Lancet Child Adolesc Health. 2020 Jun;4(6):412-414. doi: 10.1016/S2352-4642(20)30110-3. Epub 2020 Apr 17. (PMID: 32311314)