Department of Pharmacology and Pharmacy, The University of Hong Kong

Professor Paul M. VANHOUTTE 樊浩德

Visiting Professor

  • MD, PhD, DHC

Dr. Paul M. Vanhoutte was born in 1940 in Belgium, where he obtained his degrees at the University of Gent (B.S., M.S., and M.D.) and the University of Antwerpen (Agregatie Hoger Onderwijs, equivalent to Ph.D.). He received his postdoctoral training at the University of Gent and at the Mayo Clinic (Rochester, MN, USA). His academic career started at the University of Gent (Assistant, 1969-1971), followed by the Mayo Clinic (Research Associate, 1972-1973), the University of Antwerpen (Belgium; from Associate Professor to full Professor and Head of the Department of Pharmacology, 1973-1981), again the Mayo Clinic (Professor of Physiology and Pharmacology, 1981-1989) and Baylor College of Medicine (Houston TX, USA, Professor of Medicine, Pharmacology and Physiology, and Director Center for Experimental Therapeutics, 1989-1995). From 1992 to 2002, Dr. Vanhoutte was Vice-President R&D, and Director of Discovery Research at the Institut de Recherches Internationales Servier, in Courbevoie (Paris, France). During his tenure as Director of Discovery Research at Servier, he supervised the discovery and preclinical development of drugs designed for the treatment of cardiovascular diseases, diabetes, obesity, central nervous system disorders, cancer and osteoarthritis.  From 2003 to 2006 he was Distinguished Visiting Professor and Director of the BioPharmaceutical Development Centre, at the University of Hong Kong. From 2006 to 2011 he was the Head of the Department of Pharmacology and Pharmacy. From 2011 to 2015 he was Chair Professor in the same department, where he currently is permanent Visiting Professor. He currently is also part-time Professor at the University of South Denmark and Visiting Professor at the University of Zurich (Switzerland).

Professor Vanhoutte and his research associates

Professor Vanhoutte and his research associates

He also has been Visiting Professor at the National University of Rwanda, the Polish Academy of Sciences, Chonbuk National University in Jeonju (South-Korea), the University of Malaya (Kuala Lumpur), and King Saud University (Riyadh, Saudi Arabia, 2013-2015). He currently is Honorary Professor at the Shanghai Institute of Materia Medica, the Peking Union Medical College (Beijing), the Institute of Materia Medica of Beijing and the Second Military Medical University in Shanghai and. Dr. Vanhoutte is member of the Academia Europea, the Academie Nationale de Pharmacie [Paris] and the two Belgian Academies of Medicine, and honorary member of the Brazilian Academy of Medicine. He is member of the American Association of Physicians, the American Society of Physiology, the American Heart Association(Fellow), the American Society for Clinical Investigation (Emeritus), the American College of Cardiology (Fellow), the American College of Angiology (Fellow), the American Society for Pharmacology and Experimental Therapeutics, the Belgian Society for Physiology and Pharmacology, the British Pharmacological Society (Honorary Fellow), the French Pharmacological Society and the European Society of Cardiology(Fellow). He is member and Past-President of the Hong Kong Pharmacology Society. He is honorary member of the Physiological Society (London), the Chinese Pharmacological Society, the Finnish Pharmacological Society, the German Society of Angiology and the Société Française de Cardiologie.  Dr Vanhoutte is the founder and Past-President of the Serotonin Club [renamed International Society for Serotonin Research] and of the Asian Society of Vascular Biology. From 1989 to 2007, he was the Editor-in-Chief of the Journal of Cardiovascular Pharmacology. He has been Associate Editor of the American Journal of Physiology (Heart and Circulatory Physiology), of News in Physiological Sciences, and of the Journal of Vascular Medicine and Biology. He is or has been member of the Editorial Board of many scientific journals (e.g. Circulation, Circulation Research, Cardiovascular Research, Hypertension, Journal of Hypertension, American Journal of Physiology, Acta Sinica Pharmacologica, Journal of Pharmacology and Experimental Therapeutics). He has been member, and chairman, of the Program Project Review Committee of the National Heart Blood and Lung Institute of the NIH (Bethesda, MD, USA). He chaired the IUPHAR Committee for Receptor Nomenclature from 1989 to 1998. He was Secretary General of the International Union of Basic and Clinical Pharmacology (IUPHAR) from 1998 to 2002, and President of the Union from 2002 to 2006. Dr. Vanhoutte has written three theses. He has co-authored or edited 36 books. He has published 688 original research papers, and 582 editorials, reviews or chapters in books. His major scientific contribution has been to appreciate and analyse the importance of endothelial cells in the control of the underlying vascular smooth muscle in vascular health and disease, and to highlight the complexity of that regulation.  Dr. Vanhoutte has received the Doctor Honoris Causa degree of the University of Gent (Belgium) in 2001, from the Universities of Antwerp (Belgium), Montreal (Canada) and Zurich (Switzerland) in 2003, from the Royal Melbourne Institute of Technology (Australia) in 2005, from the University Louis Pasteur in Strasbourg (France) in 2006, from the Gr. T. Popa University of Medicine and Pharmacy in Iasi (Romania) in 2009, from Monash University in Melbourne (Australia) in 2012 and from the University of  South Denmark in Odense (Denmark) in 2016. Named lectures in his honor have been created by the American Society for Experimental Pharmacology and Therapeutics and by the International Society for Serotonin Research. Dr. Vanhoutte is a Highly Cited Researcher (ISI) in three categories: Biology & Chemistry, Pharmacology, and Clinical Medicine. His current h-index is 141.

Memberships and Editorships
  • Member of Academia Europea Member of Academie Nationale de Pharmacie [Paris, France]
  • Member of Academie Royale de Medecine de Belgique
  • Member of Brasilian Academy of Medicine
  • Member of Koninklijke Akademie voor Geneeskunde van België
  • American College of Cardiology, Fellow
  • American Heart Association, Fellow
  • American Physiological Society, Member
  • American Society for Clinical Investigation, emeritus Member
  • American Society for Pharmacology and Experimental Therapeutics, Member
  • Asian Society of Vascular Biology, Founder, President.
  • Association of American Physicians, Member French Pharmacological Society, Member, Past Vice-President Belgian Society for Physiology and Pharmacology, Member
  • British Pharmacological Society, Honorary Fellow
  • European Society of Cardiology, Fellow
  • Hong Kong Pharmacology Society, President [2009-present]
  • Serotonin Club, Founder; Member; Past-President
  • Société Française de Cardiologie
  • Member of The Physiological Society (London)
  • Member of Academia Europea
  • Member of Academie Nationale de Pharmacie [Paris, France]
  • Member of Academie Royale de Medecine de Belgique
  • Member of Brasilian Academy of Medicine
  • Member of Koninklijke Akademie voor Geneeskunde van Belgie

  • Consulting Editor – Cardiovascular Research 2012-2015
  • Editor-in-Chief – Journal of Cardiovascular Pharmacology 1989-2007
Honours and Awards
  • First Laureate, Interuniversity Competition of the Belgian Government (Universitaire Wedstrijd); Group: Physiological Sciences, Brussels, Belgium, 1963-1964.
  • Special prize, State University of Gent, Belgium, 1965.
  • First Laureate, Travel Grant Competition of the Belgian Government (Wedstrijd voor Reisbeurzen); Group: Pathological Sciences, Brussels, Belgium, 1965.
  • First Place, Young Investigators' Competition, The American College of Cardiology, San Francisco, California, 1973.
  • Assubel Prize, Brussels, Belgium, 1979.
  • Award for Outstanding Research, International Society for Heart Research, 1984-1985.
  • Gold Medal of the City of Paris, 1986.
  • Visiting Professorship of the British Heart Foundation, Royal Postgraduate Medical School, London W12 ONN, June 19-22, 1989.
  • Philip Dow Lecture, Medical Augusta, Georgia, November 21, 1988.
  • Lorenzini Lecture, Padova, Italy, June 14, 1989.
  • Louis F. Bishop Lecture, American College of Cardiology, New Orleans, Louisiana, March 20, 1990.
  • The Fifth George Burch Memorial Lecture, Association of University Cardiologists, Carmel, California, January 17, 1991.
  • ICI/Manchester University Prize Lecture, Manchester, United Kingdom, October 3, 1991.
  • Founders Lecture in Basic Science, Association of Academic Surgery, Colorado Springs, Colorado, November 22, 1991.
  • Invited Lecturer, Societa Italiana Di Cardiologia, 52nd Congresso Nazionale, Rome, Italy December 10-13, 1991.
  • 2nd Robert Furchgott lecture, Mechanisms of Vasodilation, Glasgow, 1993.
  • George E. Brown Lecture, American Heart Association, Atlanta, Georgia, U.S.A., November 9th, 1993.
  • CARIM Lecture 1995, Universiteit of Limburg, Maastricht, The Netherlands, November 3, 1995.
  • John T. Shepherd Lecture, Mayo Clinic and North-American chapter of the International Union of Angiology, Rochester, MN, Oct. 5, 1996.
  • 13th J. Bekaert Memorial Lecture, Antwerpen, Belgium, January 18th, 2000.
  • Thirtieth Annual Distinguished Lecture in Pharmacology, Fred W. Schueler Lecture, Tulane Medical School, New-Orleans, Louisiana, USA, June 2, 2000.
  • John Croker Lecture, American Society of Pharmacology and Experimental Therapeutics, Boston, USA, June 7th, 2000.
  • Chinese University of Hong-Kong. Distinguished Visiting Scholar 2000-2001, March 2001.
  • Institute of Scientific Information, Highly cited database researchers, 2001.
  • Ariens Lecture, The Dutch Pharmacological Society, Lenteren, March 1st, 2002.
  • Neufeld Lecture, The International Society of Cardiovascular Pharmacotherapy, Montreal, March 19th, 2002.
  • ESC Lecture on Basic Science, The European Society of Cardiology, Vienna, September 1st, 2003.
  • John Vane Lecture and Medal, 2003. The British Pharamacological Society.
  • Carl J. Wiggers Award, American Society of Physiology, 2006.
  • ‘Officer of the Crown Order’ awarded by the Belgium government, 2006.
  • Honorary Fellow of the British Pharmacological Society, 2006.
  • Honorary Fellow, Academie Royale de Medecine de Belgique, 2006.
  • Mayo Clinic Distinguished Alumni Award, Mayo Clinic, 2007.
  • Paul M. Vanhoutte Distinguished Lectureship in Vascular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2008.
  • Governor for Hong Kong, International Society of Cardiovascular Pharmacotherapy, 2008.
  • The Seventeenth Annual Thomas G. Muldoon Memorial Lecture, Medical College of Georgia, 2008.
  • The Novartis Lecture, High Blood Pressure Research Council, American Heart Association, 2010.
  • The Alexander Schirger Lectureship on Vascular Pathology, Mayo Clinic, 2011.
  • "Paul Vanhoutte Lecture” - Inaugural lecture for the Paul M Vanhoutte Award in Serotonin Pharmacology, International Society for Serotonin Research Council, July 2016.

Research Interests
  • Cardiovascular pharmacology and therapeutics. In particular endothelium-dependent relaxations, hyperpolarizations and contractions.

Selected Publications
  • Li, Z., Wang, Y., Vanhoutte, P.M. Up-regulation of Heme oxygenase-1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Hypertension , 58: 926-934, 2011.
  • Wong, M.S.K., Delansorne, R., Svenningsen, P., Vanhoutte, P.M. Chronic treatment with vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol, 299: H1226-H1234, 2010.
  • Tang, E.H.C., Vanhoutte, P.M. Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol Genomics, 32: 409-418, 2008.
  • Shi, Y, Vanhoutte, P.M. Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats. Br. J. Pharmacol., 154: 639-651, 2008.
  • Lee, M.Y.K., Tse, H.F., Siu, C.W., Zhu S.G., Man R.Y.K., Vanhoutte, P.M. Genomic changes in regenerated porcine coronary arterial endothelial cells. ATVB, 27: 2443-2449, 2007.
  • Tang, E.H.C., Feletou, M., Huang, Y., Man, R.Y.K. and Vanhoutte, P.M. Acetylcholine and Sodium Nitroprusside Cause Long-Term Inhibition of EDCF-Mediated Contraction. Am. J. Physiol Heart and Circ Physiol., 289: H2434-H2440, 2005.
  • Yang, D., Félétou, M., Levens, N., Zhang, J.N., and Vanhoutte, P.M. A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertension, 41: 143-148, 2003.
  • Shimokawa, H. and Vanhoutte, P.M. Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and in atherosclerosis. Circ. Res. 64: 900-914, 1989.
  • Rubanyi, G.M. and Vanhoutte, P.M. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor(s). Am. J. Physiol. 250: H822-H827, 1986.
  • De Mey, J.G. and Vanhoutte, P.M. Heterogeneous behavior of the canine arterial and venous wall: importance of the endothelium. Circ. Res. 51: 439-447, 1982.

Other Information

An interview with Prof Paul Vanhoutte by Dr Martin Frank, American Physiological Society
– Living History Project


8/F, Hong Kong Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Pokfulam, Hong Kong SAR, China.