Department of Pharmacology and Pharmacy, The University of Hong Kong

Dr. Jenny K.W. LAM 林嘉頴

Dr. Jenny K.W. LAM

Associate Professor

Associate Head (Undergraduate Education)

  • MPharm, PhD
Biography

Dr Jenny Lam obtained her degree in Pharmacy (MPharm) from The University of Nottingham (UK). She is registered as a pharmacist in the UK and Hong Kong. She completed her PhD in drug delivery ('Phosphorylcholine-based copolymer as synthetic vector for gene delivery') at the University of Nottingham. Shortly afterwards, she was awarded the Maplethorpe Fellowship, continued her research in nucleic acid delivery and promoted pharmaceutical education in the Department of Pharmacy at King's College London (UK). In 2009, Dr Lam joined the Department of Pharmacology and Pharmacy in the University of Hong Kong, and in 2012, she was awarded the Faculty Teaching Medal for her excellence in teaching. Her research interest is focused on the development of novel delivery system for macromolecular therapeutics including nucleic acids, proteins and peptides. She is the principal investigator of a number of research projects funded by RGC, HMRF and NSFC.

Dr. Jenny Lam and her research associates

Dr. Jenny Lam and her research associates


Memberships
  • Member of Royal Pharmaceutical Society of Great Britain
  • Member of General Pharmaceutical Council, United Kingdom
  • Specialist, Hong Kong Council for Accreditation of Academic & Vocational Qualifications
  • Registered Pharmacist, Pharmacy and Poisons Board of Hong Kong
Honours and Awards
  • DDL (Drug Delivery to the Lung) Emerging Scientist Award, The Aerosol Society UK, 2020
  • Teaching Exchange Fellowship Scheme, The University of Hong Kong; 2019
  • King's/HKU Fellowship Award, HKU, 2013-14
  • Faculty Teaching Medal, LKS Faculty of Medicine, HKU 2012
  • CW Maplethorpe Fellowship, The University of London, UK 2007-2009

Research Interests
  • Investigate the cellular uptake pathway and intracellular trafficking of macromolecules
  • Design and characterise novel polymer and peptide for nucleic acids delivery
  • Development of intranasal and inhalation delivery system for therapeutic nucleic acids, proteins and peptides
  • Development of antimicrobial peptides as new class of antibacterial agents
Scanning electron microscopic image of inhalable dry powder of siRNA prepared by spray drying and spray freeze drying. Left: spray freeze dried powder; Right: Spray dried powder

Scanning electron microscopic image of inhalable dry powder of siRNA prepared by spray drying and spray freeze drying. Left: spray freeze dried powder; Right: Spray dried powder


Luciferase expression in the lungs after pulmonary delivery of luciferase plasmid DNA to C57BL/6N mouse at 24h post-transfection. Bioluminescence image of dissected lungs was acquired with the IVIS 100 Spectrum imaging system.

Luciferase expression in the lungs after pulmonary delivery of luciferase plasmid DNA to C57BL/6N mouse at 24h post-transfection. Bioluminescence image of dissected lungs was acquired with the IVIS 100 Spectrum imaging system.



Publications
Original Research Articles

Selected Publications (*corresponding author)

  • Qiu Y, Man RCH, Liao Q, Kung KLK, Chow MYT, Lam JKW*. Effective mRNA pulmonary delivery by dry powder formulation of a PEGylated synthetic KL4 peptide. Journal of Controlled Release 2019; 314, 102-115 (Click here for abstract)
  • Liao Q, Yip, L, Chow MYT, Chow SF, Chan HK, Kwok PCL, Lam JKW*. Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition. International Journal of Pharmaceutics 2019; 560: 144-154 (Click here for abstract)
  • Man DWK, Kanno T, Manzo G, Robertson BD, Lam JKW, Mason AJ. Rifampacin- or Capreomycin induced remodelling of the Mycobacterium smegmatis myolic acid layer is mitigated in synergistic combinations with cationic antimicrobial peptides. mSphere 2018; 3(4): e00218-18 (Click for abstract)
  • Qiu Y, Chow MYT, Liang W, Chung WY, Mak J, Lam JKW*. From pulmonary surfactant – synthetic KL4 peptide as effective siRNA delivery vector for pulmonary delivery. Molecular Pharmaceutics. 2017; 14(2): 4606-4617 (Click for abstract)
  • Chow MYT, Qiu Y, Lo FFK, Lin HHS, Chan HK, Kwok PCL, Lam JKW*. Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer. International Journal of Pharmaceutics. 2017; 530(1-2): 40-52 (Click for abstract)
  • Xu Y, Liang W, Qiu Y, Cespi M, Palmieri GF, Mason AJ, Lam JKW*. Incorporation of a nuclear localization signal in pH responsive LAH4-L1 peptides enhances transfection and nuclear uptake of plasmid DNA. Molecular Pharmaceutics. 2016; 13(9): 3141-3152 (Click for abstract)
  • Kwok PCL, Grabarek A, Chow MYT, Lan Y, Li JCW, Casettari L, Mason AJ, Lam JKW*. Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis. International Journal of Pharmaceutics. 2015; 491(1-2): 367-374 (Click for abstract)
  • Liang W, Chow MYT, Lau PN, Zhou QT, Kwok PCL, Leung GPH, Mason AJ, Chan HK, Poon LLM, Lam JKW*. Inhalable dry powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus. Molecular Pharmaceutics 2015; 12(3): 910-921 (Click for abstract)
  • Liang W, Kwok PCL, Chow MYT, Tang P, Mason AJ, Chan HK, Lam JKW*. Formulation of pH responsive peptide as inhalable dry powders for pulmonary delivery of nucleic acids.European Journal of Pharmaceutics and Biopharmaceutics. 2014; 86 (1): 64-73 (Click for abstract)
  • Lam JKW, Liang W, Lan Y, Chaudhuri P, Chow MYT, Witt K, Kudsiova L, Mason AJ.Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways. Journal of Controlled Release. 2012; 158 (2): 293-303 (Click for abstract)

List of publications


Funding
External Peer-Reviewed Competitive Grants (as Principal Investigator)
  • Bio-inspired PEGylated KL4 peptide as non-viral vector for pulmonary delivery of nucleic acid-based therapeutics, General Research Fund (GRF), Research Grant Council (RGC) (17300319) Jan 2020 - Dec 2022
  • Novel inhalable powder formulations of synergistic combinations of antimicrobial peptides and antitubercular drugs to combat drug-sensitive and drug-resistant tuberculosis, Health and Medical Research Fund (HMRF) (18170972) Jul 2019 - Jun 2022
  • High-performance inhaled powder formulation of RNAi therapeutics by co-spray drying of RNA with human serum albumin, General Research Fund (GRF), Research Grant Council (RGC) (17301918) Jan 2019 - Dec 2020
  • Inhalable dry powder formulation of naked siRNA using spray-drying and spray freeze-drying technologies for the treatment of respiratory infections’ Health and Medical Research Fund (HMRF) (15140962) Apr 2016 - Feb 2019
  • Development of a highly efficient inhalable mucosal DNA vaccine against HIV as dry powder using pH responsive LAH peptides with nuclear localizing sequence as DNA carrier, General Programme, National Natural Science Foundation of China (NSFC) (81573373) Jan 2016 - Dec 2019
  • Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery, General Research Fund (GRF), Research Grant Council (RGC) (17302815) Jan 2016 - Jun 2019
  • Development of a highly effective, pH responsive peptide, siRNA delivery system to the respiratory tract to combat influenza virus infections, General Research Fund (GRF), Research Grant Council (RGC) (17110414) Jan 2015 - Dec 2017
  • Intranasal delivery of DNA vaccine using oligochitosan/PLGA nanoparticles, Health and Medical Research Fund (HMRF) (13121222) Apr 2014 - Mar 2015
  • The investigation of antimicrobial peptide as novel therapy for Mycobacterium tuberculosis, Research Fund for the Control of Infectious Disease (RFCID) (11100682) Oct 2011 - Sep 2012

Patents
  • Lam JKW, Qiu Y, Chow MYT. PEGylated synthetic KL4 peptide, Compositions and Methods Thereof. (PCT/CN2020/101299) filed on 10 July 2020.
  • Lam JKW, Pan HW, Lo CKJ. Inhaled powder formulations for respiratory delivery of antibodies. (US Provisional Application No. 63/117,772) filed on 24 November 2020.
  • Lam JKW, Qiu Y, Chow MYT. PEGylated synthetic KL4 peptide, Compositions and Thereof. (US Provisional Application No. 62/872,336) filed on July 2019.

Other Information
Seeking Postgraduate Students and Research Assistants

We are inviting highly motivated graduate students who are interested in the area of drug delivery and translational research to join the group. Our group is focused on the development of pulmonary nucleic acid delivery system, and new antimicrobial therapy for respiratory infectious diseases such as tuberculosis and influenza. Candidates with a background in pharmaceutical science, drug delivery or microbiology may have an advantage. For further information, please email Dr Jenny Lam with your CV (email: jkwlam@hku.hk).

Current Group Members
  • Dr Carol Yingshan QIU (Postdoctoral Fellow)
  • Miss Rachel Qiuying LIAO (PhD Student)
  • Mr Rico Chi-Hang MAN (HKU/KCL Joint PhD Student)
  • Mr Harry Weijie PAN (PhD Student)
  • Mr Hancong SEOW (MPhil Student)
  • Miss Zitong SHAO (MPhil Student)
  • Mr Jason Chun-Kit LO (Research Assistant)
  • Miss Joyce Pui Man FAN (Research Assistant)
Drug Delivery Research Group

Drug Delivery Research Group


Key Research Collaborators
  • Professor Hak-Kim CHAN, Professor, Sydney Pharmacy School, The University of Sydney, Australia
  • Professor Leo Lit-Man POON, Professor, School of Public Health, The University of Hong Kong
  • Dr Luca CASETTARI, Associate Professor, School of Pharmacy, University of Urbino, Italy
  • Dr A. James MASON, Reader, Institute of Pharmaceutical Sciences, King’s College London, UK
  • Dr Brian ROBERTSON, Reader, Faculty of Medicine, Imperial College London, UK
Alumni
  • Dr Dede Kwun-Wai MAN (HKU/KCL Joint PhD 2019)
  • Dr Michael Yee-Tak CHOW (PhD 2018)
  • Dr Yingying XU (PhD 2017)
  • Dr Yun LAN (PhD 2015)
  • Dr Wanling LIANG (PhD 2014)
Regular Student Consultation Hours
Every Friday at 9:00am - 10:00am
Office

2/F, 21 Sassoon Road, Li Ka Shing Faculty of Medicine, Laboratory Block, Faculty of Medicine Building, Hong Kong SAR, China. Email: jkwlam@hku.hk