Dr. Jenny KW Lam
Associate Professor
Dr. Jenny KW Lam
Department of Pharmacology and Pharmacy
The University of Hong Kong
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Dr. Jenny Lam and her research associates
Dr. Jenny Lam and her research associates

Associate Professor

Dr. Jenny Ka-Wing Lam (林嘉頴)
MPharm(Hons), PhD Nott UK

  • Member of American Society of Gene & Cell Therapy
  • Member of Royal Pharmaceutical Society of Great Britain
  • Member of General Pharmaceutical Council, United Kingdom
  • Member of Controlled Release Society
  • Member of Centre of Influenza Research, The University of Hong Kong
  • Specialist, Hong Kong Council for Accreditation of Academic & Vocational Qualifications
  • Registered Pharmacist, Pharmacy and Poisons Board of Hong Kong

Biography

Dr Jenny Lam obtained her degree in Pharmacy (MPharm) from The University of Nottingham (UK). She is registered as a pharmacist in the UK and Hong Kong. She completed her PhD in drug delivery ('Phosphorylcholine-based copolymer as synthetic vector for gene delivery') at the University of Nottingham. Shortly afterwards, she was awarded the Maplethorpe Fellowship, continued her research in nucleic acid delivery and promoted pharmaceutical education in the Department of Pharmacy at King's College London (UK). In 2009, Dr Lam joined the Department of Pharmacology and Pharmacy in the University of Hong Kong, and in 2012, she was awarded the Faculty Teaching Medal for her excellence in teaching. Her research interest is focused on the development of novel delivery system for macromolecular therapeutics including nucleic acids, proteins and peptides. She is the principal investigator of a number of research projects funded by RGC, HMRF and NSFC.

Honours and Awards

  • Visiting Senior Lecturer, Institute of Pharmaceutical Science, King’s College London, UK, 2015 – Present
  • King's/HKU Fellowship Award, HKU, 2013-14
  • Faculty Teaching Medal, LKS Faculty of Medicine, HKU 2012
  • CW Maplethorpe Fellowship, The University of London, UK 2007-2009

My Research Interests

  • Investigate the cellular uptake pathway and intracellular trafficking of macromolecules
  • Design and characterise pH responsive polymer and peptide for nucleic acids (e.g. DNA and siRNA) delivery
  • Development of intranasal and inhalation delivery system for therapeutic nucleic acids, proteins and peptides
  • Development of antimicrobial peptides as new class of antibacterial agents

Scanning electron microscopic image of inhalable dry powder of siRNA prepared by spray drying and spray freeze drying. Left: spray freeze dried powder; Right: Spray dried powder

Luciferase expression in the lungs after pulmonary delivery of luciferase plasmid DNA to C57BL/6N mouse at 24h post-transfection. Bioluminescence image of dissected lungs was acquired with the IVIS 100 Spectrum imaging system.

Selected Publications(*corresponding author)

List of Publications

Selected Original Research Articles

  • Liang W, Chow MYT, Chow SF, Chan HK, Kwok PCL, Lam JKW*. Using two-fluid nozzle for spray freeze drying to produce porous powder formulation of naked siRNA for inhalation. International Journal of Pharmaceutics 2018 (In Press) (Click here for abstract)
  • Qiu Y, Chow MYT, Liang W, Chung WY, Mak J, Lam JKW*. From pulmonary surfactant – synthetic KL4 peptide as effective siRNA delivery vector for pulmonary delivery. Molecular Pharmaceutics. 2017; 14(2): 4606-4617 (Click here for abstract)
  • Chow MYT, Qiu Y, Lo FFK, Lin HHS, Chan HK, Kwok PCL, Lam JKW*. Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer. International Journal of Pharmaceutics. 2017; 530(1-2): 40-52 (Click for abstract)
  • Xu Y, Liang W, Qiu Y, Cespi M, Palmieri GF, Mason AJ, Lam JKW*. Incorporation of a nuclear localization signal in pH responsive LAH4-L1 peptides enhances transfection and nuclear uptake of plasmid DNA. Molecular Pharmaceutics. 2016; 13(9): 3141-3152 (Click for abstract)
  • Kwok PCL, Grabarek A, Chow MYT, Lan Y, Li JCW, Casettari L, Mason AJ, Lam JKW*. Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis. International Journal of Pharmaceutics. 2015; 491(1-2): 367-374 (Click for abstract)
  • Man DKW, Casettari L, Cespi M, Bonacucina G, Palmieri GF, Sze SCW, Leung GPH, Lam JKW*, Kwok PCL. Oleanolic acid loaded PEGylated PLA and PLGA nanoparticles with enhanced cytotoxic activity against cancer cells. Molecular Pharmaceutics. 2015; 12(6): 2112-2125 (Click for abstract)
  • Liang W, Chow MYT, Lau PN, Zhou QT, Kwok PCL, Leung GPH, Mason AJ, Chan HK, Poon LLM, Lam JKW*. Inhalable dry powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus. Molecular Pharmaceutics 2015; 12(3): 910-921 (Click for abstract)
  • Liang W, Kwok PCL, Chow MYT, Tang P, Mason AJ, Chan HK, Lam JKW*. Formulation of pH responsive peptide as inhalable dry powders for pulmonary delivery of nucleic acids. European Journal of Pharmaceutics and Biopharmaceutics. 2014; 86 (1): 64-73 (Click for abstract)
  • Lan Y, Lam JT, Siu GKH, Yam WC, Mason AJ, Lam JKW*. Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis. Tuberculosis. 2014; 94 (6): 678-689 (Click for abstract)
  • Lam JKW, Liang W, Lan Y, Chaudhuri P, Chow MYT, Witt K, Kudsiova L, Mason AJ. Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways. Journal of Controlled Release. 2012; 158 (2): 293-303 (Click for abstract)

Selected Review Articles

  • Man DKW, Chow MYT, Casettari L, Gonzalez-Juarrero M, Lam JKW*. Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis. Advanced Drug Delivery Reviews. 2016; 102: 21-32 (Click for abstract)
  • Chow MYT, Lam JKW*. Dry powder formulation of plasmid DNA and siRNA for inhalation. Current Pharmaceutical Design. 2015; 21(27): 3854-3866 (Click for abstract)
  • Lam JKW*, Chow MYT, Zhang Y, Leung SWS. siRNA vs miRNA as therapeutics for gene silencing. Molecular Therapy – Nucleic Acids. 2015; 4:e252 (Click for abstract)
  • Lam JKW*, Liang W, Chan HK. Pulmonary delivery of therapeutic siRNA. Advanced Drug Delivery Reviews. 2012; 64 (1): 1-15 (Click for abstract)

List of Publications

External Peer-Reviewed Competitive Grants
(as Principal Investigator)

  • ‘High-performance inhaled powder formulation of RNAi therapeutics by co-spray drying of RNA with human serum albumin’ (2019-2021) General Research Fund (GRF), Research Grant Council (RGC) (17301918)
  • ‘Inhalable dry powder formulation of naked siRNA using spray-drying and spray freeze-drying technologies for the treatment of respiratory infections’ (2016-2018) Health and Medical Research Fund (HMRF) (15140962)
  • ‘Development of a highly efficient inhalable mucosal DNA vaccine against HIV as dry powder using pH responsive LAH peptides with nuclear localizing sequence as DNA carrier’ (2016-2019) General Programme, National Natural Science Foundation of China (NSFC) (81573373)
  • ‘Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery’ (2015-2018) General Research Fund (GRF), Research Grant Council (RGC) (17302815)
  • ‘Development of a highly effective, pH responsive peptide, siRNA delivery system to the respiratory tract to combat influenza virus infections’ (2015-2018) General Research Fund (GRF), Research Grant Council (RGC) (17110414)
  • ‘Intranasal delivery of DNA vaccine using oligochitosan/PLGA nanoparticles’ (2014-2015) Health and Medical Research Fund (HMRF) (13121222)
  • ‘The investigation of antimicrobial peptide as novel therapy for Mycobacterium tuberculosis’ (2011-2012) Research Fund for the Control of Infectious Disease (RFCID), (11100682)

Seeking Postgraduate Students and Research Assistants:

We are inviting highly motivated graduate students who are interested in the area of drug delivery and translational research to join the group. Our group is focused on the development of pulmonary nucleic acid delivery system, and new antimicrobial therapy for respiratory infectious diseases such as tuberculosis and influenza. Candidates with a background in pharmaceutical science, drug delivery or microbiology may have an advantage. For further information, please email Dr Jenny Lam with your CV (email: jkwlam@hku.hk).

Drug Delivery Research Group

Current Group Members

  • Dr CHOW Yee Tak, Michael (Postdoc Research Associate)
  • Miss MAN Kwun Wai, Dede (HKU/KCL Joint PhD student)
  • Miss QIU Yingshan, Carol (PhD student)
  • Miss LIAO Qiuying, Rachel (MPhil student)
  • Mr MAN Chi Hang, Rico (Research Assistant)
  • Mr LO Chun Kit, Jason (BBMS student)

Alumni

  • Dr CHOW Yee Tak, Michael (PhD 2018)
  • Dr XU Yingying, Lily (PhD 2017)
  • Dr LAN Yun, Yolanda (PhD 2015)
  • Dr LIANG Wanling, Sophia (PhD 2014)

 

Key Research Collaborators

  • Prof Hak-Kim CHAN, Professor, Sydney Pharmacy School, The University of Sydney, Australia
  • Professor Leo Lit-Man POON, Professor, School of Public Health, The University of Hong Kong
  • Dr Luca CASETTARI, Associate Professor, School of Pharmacy, University of Urbino, Italy
  • Dr A. James MASON, Reader, Institute of Pharmaceutical Sciences, King’s College London, UK

Office:

2/F, 21 Sassoon Road, Li Ka Shing Faculty of Medicine, Laboratory Block, Faculty of Medicine Building, Hong Kong SAR, China. Email: jkwlam@hku.hk