Department Research Output List ( JUL 2014 to JUN 2015)

Journal publications

  • Beckmann J, Hagemann U, Bahri P, Bate A, Boyd IW, Dal Pan GJ, Edwards BD, Edwards IR, Hartigan-Go K, Lindquist M, McEwen J, Moride Y, Olsson S, Pal SN, Soulaymani-Bencheikh R, Tuccori M, Vaca CP, Wong ICK. Teaching pharmacovigilance: the WHO-ISoP core elements of a comprehensive modular curriculum. Drug Saf 2014; 37:743-759.
  • Cai Y, Manio MM, Leung GPH, Xu A, Tang EHC, Vanhoutte PMGR. Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries. Eur J Pharmacol 2015; 747:18-28.
  • Chui SLC, Wong ICK, Wong LYL, Chan EW. Association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies. J Antimicrob Chemother 2015; 70:971-978.
  • Chan EW, Lau CY, Leung WK, Mok MTC, He Y, Tong SM, Wong ICK. Prevention of dabigatran-related gastrointestinal bleeding with gastroprotective agents: a population-based study. Gastroenterology 2015; 149:586-595.
  • Chen H, Li S, Wang P, Yan S, Hu L, Pan X, Yang C, Leung GPH. Endothelium-dependent and -independent relaxation of rat aorta induced by extract of Schizophyllum commun. Phytomedicine 2014; 21:1230-1236.
  • Chen Z, Zhang X, Ying L, Dou D, Li Y, Bai Y, Liu J, Feng H, Yu X, Leung SWS, Vanhoutte PMGR, Gao Y. Cyclic IMP-synthesized by sGC as a mediator of hypoxic contraction of coronary arteries. Am J Physiol Heart Circ Physiol 2014; 307:H328-H336.
  • Cheung CL, Lam KSL, Wong ICK, Cheung BMY. Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA. BMC Medicine 2014; 12:154.
  • Cheung KKW, Wong ICK, Ip P, Chan PKL, Lin HYC, Wong LYL, Chan EW. Experiences of adolescents and young adults with ADHD in Hong Kong: treatment services and clinical management. BMC Psychiatry 2015; 15:95.
  • Cui GZ, Luk CWS, Li RA, Chan KKK, Lei SW, Wang L, Shen HF, Leung GPH, Lee SMY. Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway. J Cardiovasc Pharmacol 2015; 65:39-46.
  • Djabri A, van't Hoff W, Brock P, Wong ICK, Guy RH, Delgado-Charro B. Iontophoretic transdermal sampling of iohexol as a non-invasive tool to assess glomerular filtration rate. Pharm Res 2015; 32:590-603.
  • Dufay S, Worsley AJ, Monteillier A, Avanzi C, Sy LK, Ng TF, Garcia JM, Lam MF, Vanhoutte PMGR, Wong ICK. Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro. J Pharm Pharmacol 2014; 66:1478-1490.
  • Emoto N, Masaki T, Goto K, Vanhoutte PMGR, Yanagisawa M. Endothelin XIII, Life Sci 2014; 118:47-50. Gao Y, Chen Z, Leung SWS, Vanhoutte PMGR. Hypoxic vasospasm mediated by cIMP. J Cardiovasc Pharmacol 2015; 65:545-548.
  • Gao YS, Vanhoutte PMGR. Tissues cIMPly do not lie. Naunyn Schmiedebergs Arch Pharmacol 2014; 387:901-903.
  • He Y, Chan EW, Man KCK, LAU CY, Leung WK, Ho LM, Wong ICK. Dosage effects of histamine-2 receptor antagonist on the primary prophylaxis of non-steroidal anti-inflammatory drug (NSAID)-associated peptic ulcers: a retrospective cohort study. Drug Saf 2014; 37:711-721.
  • He Y, Chan EW, Leung WK, Anand S, Wong ICK. Systematic review with meta-analysis: the association between the use of calcium channel blockers and gastrointestinal bleeding. Aliment Pharmacol Ther 2015; 41:1246-1255.
  • Ho MH, Ho CW, Cheung E, Chan PHM, Hai JJ, Chan KH, Chan EW, Leung GKK, Tse HF, Siu DCW. Continuation of dabigatran therapy in “real-world” practice in Hong Kong. PLoS ONE 2014; 9(8):e101245.
  • Hsu WWQ, Chan EW, Zhang Z, Lin ZX, Bian ZX, Hsia Y, Wong ICK. A survey to investigate attitudes and perceptions of Chinese medicine professionals in health information technology in Hong Kong. Eur J Integr Med 2015; 7:36-46.
  • Hsu WWQ, Chan EW, Zhang Z, Lin ZX, Bian ZX, Wong ICK. Chinese medicine students’ view on electronic prescribing: A survey in Hong Kong. Eur J Integr Med 2015; 7:47-54.
  • Kong WCB, Man RYK, Gao YS, Vanhoutte PMGR, Leung SWS. Reduced activity of SKCa and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats. Pharma Res Per 2015; 3:1-11.
  • Kong WCB, Vanhoutte PMGR, Man RYK, Leung SWS. 17β-estradiol potentiates endothelium-dependent nitric oxide- and hyperpolarization-mediated relaxations in blood vessels of male but not female apolipoprotein-E deficient mice. Vascul Pharmacol 2015; 71:166-173.
  • Kendall J, Maconochie I, Wong ICK, Howard R. A novel multipatient intranasal diamorphine spray for use in acute pain in children: pharmacovigilance data from an observational study. Emerg Med J 2015; 32:269-273.
  • Kwok PCL. Pharmaceutical aerosol electrostatics: A field with much potential for development. Ther Deliv 2015; 6:105-107.
  • Lan Y, Lam JT, Siu GKH, Yam WC, Mason AJ, Lam JKW. Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis. Tuberculosis 2014; 94:678-689.
  • Liang W, Chow YT, Lau PN, Zhou QT, Kwok PCL, Leung GPH, Mason AJM, Chan HK, Poon LLM, Lam JKW. Inhalable powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus. Mol Pharmaceutics 2015; 12:910-921.
  • Lai ECC, Man KCK, Chaiyakunapruk N, Cheng CL, Chien HC, Chui SLC, Dilokthornsakul P, Chantelle HN, Hsieh CY, Hsu C.Y. Databases in the Asia-Pacific region: the potential for a distributed network approach. Epidemiology 2015; 1
  • Lam JKW, Worsley AJ. What is the future of siRNA therapeutics?, J Drug Des Res 2014; 1:1005. Lee CHP, Woo YC, Wang Y, Yeung CY, Xu A, Lam KSL. Obesity, adipokines and cancer: an update. Clin Endocrinol 2014; 83:147-156.
  • Leung TY, Park TJ, Wang Y, Che CM, Leung KMY. Isoform-specific responses of metallothioneins in a marine pollution biomonitor, the green-lipped mussel Perna viridis, towards different stress stimulations. Proteomics 2014; 14:1796-1807.
  • Li M, Fan P, Wang Y. Integrative approaches for lipid analysis. Pharmacologia 2015; 6:213-234.
  • Li M, Fan P, Wang Y. Lipidomics in health and diseases - beyond the analysis of lipids. J Glycomics Lipidomics 2014; 5:126.
  • Li S, Zhou XL, Dang YY, Kwan YW, Chan SW, Leung GPH, Lee SMY, Hoi MPM. Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis, Biochimica et Biophysica Acta (BBA) - General Subjects 2015; 1850:373-384.
  • Li S, Dang YY, Che OLG, Kwan YW, Chan SW, Leung GPH, Lee SMY, Hoi MPM. VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicol Appl Pharmacol 2014; 280:408-420.
  • Li WSR, Yang C, Chan SW, Hoi MPM, Lee SMY, Kwan YW, Leung GPH. Relaxation effect of abacavir on rat basilar arteries. PLoS One 2015; 10(4):e0123043
  • Li WSR, Yang C, Sit SM, Kwan YW, Lee SMY, Hoi MPM, Chan SW, Hausman M, Vanhoutte PMGR, Leung GPH. Uptake and Protective effects of Ergothioneine in Human Endothelial Cells. J Pharmacol Exp Ther 2014; 350:691-700.
  • Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Hong D, Triggle C, Xu A. FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes 2014; 63:4064-4075.
  • Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, Triggle C, Wang K, Li X, Xu A. Fibroblast growth gactor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation 2015; 131:1861-1871.
  • Man KCK, Ip P, Hsia Y, Chan EW, Chui SLC, Lam MPS, Wong WHS, Chow CB, Yung AWY, Wong ICK. ADHD drug prescribing trend is increasing among children and adolescents in Hong Kong. J Atten Disord 2014 Jul 3.
  • Man KCK, Tong HYH, Wong LYL, Chan EW, Simonoff E, Wong ICK. Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies. Neurosci Biobehav Rev 2014; 49:82-89.
  • Man KCK, Chan EW, Coghill D, Douglas I, Ip P, Leung LP, Tsui MSH, Wong WHS, Wong ICK. Methylphenidate and the risk of trauma. Pediatrics 2014; 135:40-48.
  • Man KWD, Casettari L, Cepsi C, Bonacucina G, Palmieri F, Sze CWS, Leung GPH, Lam JKW, Kwok PCL. Oleanolic acid loaded PEGylated PLA and PLGA nanoparticles with enhanced cytotoxic activity against cancer cells. Mol Pharmaceutics 2015; 12:2112-2125.
  • Mao L, Lin W, Nie T, Hui X, Gao X, Li K, Ding M, Tang X, Li P, Wang Y, Xu A, Liu P, Wu D. Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell & Bioscience 2014; 4:60.
  • Osto E, Doytcheva P, Corteville C, Bueter M, Dorig C, Stivala S, Buhmann H, Colin S, Rohrer L, Hasballa R, Tailleux A, Wolfrum C, Tona F, Manz J, Vetter D, Spliethoff K, Vanhoutte PMGR, Landmesser U, Pattou F, Staels B, Matter CM, Lutz TA, Luscher TF. Rapid and body weight-independent improvement of endothelial and high-density lipoprotein function after Roux-en-Y gastric bypass: role of glucagon-like peptide-1. Circulation 2015; 131:871-881.
  • Pratt N, Chan EW, Choi NK, Kimura M, Kimura T, Kubota K, Lai ECC, Man KCK, Ooba N, Park BJ, Sato T, Shin JY, Wong ICK, Kao Yang YH, Roughead EE. Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries. Pharmacoepidemiol Drug Saf 2015; 24:858-864.
  • Raffai G, Khang G, Vanhoutte PMGR. Vanillin and vanillin analogs relax porcine coronary and basilar arteries by inhibiting L-type Ca2+ channels. J Pharmacol Exp Ther 2014; 352:14-22.
  • Samaranayake NR, Cheung DS, Lam MPS, Cheung TT, Chui WCM, Wong ICK, Cheung BMY. The effectiveness of a 'Do Not Use' list and perceptions of healthcare professionals on error-prone abbreviations. Int J Clin Pharm 2014; 36:1000-1006.
  • Svenningsen P, Andersen K, Thuesen AD, Shin HS, Vanhoutte PMGR, Skett O, Jensen BL, Hill C, Hansen PBL. T-type Ca2+ channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressure. Pflugers Arch 2014; 466:2205-2214.
  • Tang EHC, Cai Y, Wong CK, Rocha VZ, Sukhova GK, Shimizu K, Ge X, Vanhoutte PMGR, Libby P, Xu A. Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue. J Lipid Res 2015; 56:358-368.
  • Tsang CM, Cheung KC, Cheung YC, Man K, Lui WYV, Feng Y, Tsao GSW. Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma. Biochim Biophys Acta 2014; 1852:541-551.
  • Tsui PY, Cheung CW, Lee Y, Leung SWS, Ng JKF. The effectiveness of low-dose desmopressin in improving hypothermia-induced impairment of primary haemostasis under influence of aspirin - a randomized controlled trial. BMC Anesthesiol 2015; 15:80.
  • Vanhoutte PMGR. PDE and sGC hand in hand to see the light. Proc Natl Acad Sci U S A 2014; 111:17704-17705.
  • Wong KL, Wong RN, ZHANG L, Liu WK, Ng TB, Shaw PC, Kwok PCL, Lai YM, Zhang Z, Zhang Y, Tong Y, Cheung HP, LU J, Sze CW. Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential. Chinese medicine 2014; 9:19.
  • Wang Y. Molecular links between caloric restriction and Sir2/SIRT1 activation. Diabetes Metab J 2014; 38:321-329.
  • Wong ICK, Ng YK, Lui WYV. Cancers of the lung, head and neck on the rise: perspectives on the genotoxicity of air Pollution. Chinese Journal of Cancer 2014; 33:476-480.
  • Wong J, Kwok PCL, Noakes T, Fathi A, Dehghani F, Chan H.K. Effect of crystallinity on electrostatic charging in dry powder inhaler formulations. Pharm Res 2014; 31:1656-1664.
  • Xu Y., Yuen PW, Lam JKW. Intranasal DNA vaccine for protection against respiratory infectious diseases: the delivery perspectives. Pharmaceutics 2014; 6:378-415.
  • Xu C, Cai Y, Fan P, Bai B, Chen J, Deng H, Che CM, Xu A, Vanhoutte PMGR, Wang Y. Calorie restriction prevents metabolic aging caused by abnormal SIRT1 function in adipose tissues. Diabetes 2015; 64:1576-1590.
  • Xu YC, Leung SWS, Leung GPH, Man RYK. Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca 2+ -activated K + channels. Br J Pharmacol 2015; 172:3003-3014.
  • Yang C, Leung GPH. Equilibrative nucleoside transporters 1 and 4. J Cardiovasc Pharmacol 2015; 65:517-521.
  • Ye D, Wang Y, Li H, Jia W, Man K, Lo CM, Wang Y, Lam KSL, Xu A. Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice. Hepatology 2014; 60:977-989.
  • Zhao Y, Flavahan S, Leung SWS, Xu A, Vanhoutte PMGR, Flavahan NA. Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling. Am J Physiol Heart Circ Physiol 2015; 308:H358-H363.
  • Zou Q, Leung SWS, Vanhoutte PMGR. TRP channel opening releases endogenous acetylcholine which contributes to endothelium-dependent relaxations induced by mild hypothermia in SHR but not WKY arteries. J Pharmacol Exp Ther 2015; 354:121-130.
  • Zhang L, Wong LYL, He Y, Wong ICK. Pharmacovigilance in china: current situation, successes and challenges. Drug Saf. 2014; 37:765-770.