Antibody and Immunoassay Services, HKU
Antibody and Immunoassay Services, HKU

 

CRP (human), rabbit polyclonal

Polyclonal Antibody against Human CRP

Host:

Rabbit

Cat. No.:

11120

Size:

1 mg

Files:

Isotype/Preparation:

Rabbit crude IgG was purified by protein-G column

Immunogen:

ecombinant full-length human CRP expressed in E.Coli

Specificity:

The antibody detects circular human CRP

Formulation:

Solution in PBS.

Storage:

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles

Application/Usage:

ELISA - This antibody can be used at 0.1~0.2 μg/mL as detection antibody in human CRP ELISA

Introduction

C-reactive protein (CRP) is a circulating protein mainly secreted from the liver. This acute phase protein consists of five identical non-glycosylated subunits of 23 kDa, that give rise to a symmetrically arranged globular protein with molecular weight of approximately 120 kDa.[1] It has long been recognized that CRP is closely related to immunology, inflammation and host defense; as a result it has been used as an inflammatory marker. Normally CRP is presenting only in a trace amount in circulation (<1 μg/ml)[2,3] but can increase over 1,000-fold under acute inflammatory state. Individual with blood CRP levels <1 μg/ml, 1-3 μg/ml and >3 μg/ml is considered to have low, moderate and high risk, respectively, of CVD and myocardial infraction.[4 ]Therefore, blood CRP level has become a promising measure of CVD risk.[5,6]

Reference:
1. Thompson D., Pepys M.B. and Wood S.P. (1999) Structure, 7, 169-177.
2. Kindmark C.O. (1972) Scand J Clin Lab Invest, 29, 407-411.
3. Macy E.M., Hayes T.E. and Tracy R.P. (1997) Clin Chem, 43, 52-58.
4. Ridker P.M. (2004) Am Heart Hosp J, 2 (4 Suppl 1), 4-9.
5. Benzaquen l.R., Yu H. and Rifai N. (2002) Crit Rev Clin Lab Sci, 39, 459-497.
6. Pearson T.A. et al., (2003) Circulation, 107, 499-511.

 

 

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