Professor A Xu
Department of Pharmacology & Pharmacy, The University of Hong Kong
Professor Aimin Xu (徐愛民)
BMed Anhui, MSc, PhD Auck
Director, State Key Laboratory of Pharmaceutical Biotechnology, HKU (www.sklpb.hku.hk)
Director, Antibody and Immunoassay Services, HKU
Deputy Chair, Biochemical Journal
American Diabetes Association
American society of Biochemistry and Molecular Biology HBHA center, HKU
Editor: Clinical Science, PLOS One
Editorial Board member, Journal of Obesity, Journal of Diabetes, Adipocytes, Cardiovascular Drugs and Therapy Editor
Obesity is a major risk factor of type 2 diabetes (T2DM), insulin resistance and cardiovascular diseases (CVDs). In obesity, chronic metabolic stresses trigger adipose tissue inflammation and promote macrophage infiltration, resulting in aberrant secretion of bioactive peptides (known as adipokines). Our primary research interest is to investigate the role of adipokines in the pathogenesis of obesity-related insulin resistance, systemic inflammation, T2DM and vascular dysfunctions in animal models and human subjects. Our long-term goal is to develop adipokine-based diagnostic and therapeutic strategies for obesity-related cardio-metabolic complications.
Professor Xu and his research associates (click image to enlarge)
Hui X, Gu P, Zhang J, Nie T, Pan Y, Wu D, Feng T, Zhong C, Wang Y, Lam KSL, Xu A*. Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Cell Metab. 2015 Aug 4; 22(2):279-290.
Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, Triggle C, Wang K, Li X*, Xu A*. Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. Circulation. 2015 Mar 26;131(21):1861-71.
Yau SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, Xu A*, So KF*. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15810-5.
Ye D, Wang Y, Li H, Jia W, Man K, Lo CM, Wang Y, Lam KSL*, Xu A*. Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice. Hepatology. 2014 Sep;60(3):977-89. (Selected for commentary @ Fibroblast growth factor 21: a new liver safeguard. [Hepatology. 2014])
Wang Y, Xiao Y, Zhong L, Ye D, Zhang J, Tu Y, Bornstein SR, Zhou Z*, Lam KS*, Xu A*. Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated with β-cell Autoimmunity in Patients with Type 1 Diabetes. Diabetes. 2014 Dec;63(12):4239-48 . (Selected for commentary @ Autoimmune diabetes: caught in a NET. [Diabetes. 2014])
Cheng KKY*, Zhu W, Chen B, Wang Y, Wu D, Sweeney G, Wang B, Lam KSL, Xu A*, The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes, 2014 Nov;63(11):3748-58.
Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KSL*, Xu A*. FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting. Diabetes. 2014 Dec;63(12):4064-75 (Selected for commentary @ Head over hepatocytes for FGF21. [Diabetes. 2014])
Lin Z, Wu F, Lin S, Pan X, Jin L, Lu T, Shi L, Wang Y, Xu A*, Li X*. Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice. J Hepatol, 2014 Oct;61(4):825-31
Hoo RLC, Lee IPC, Zhou M, Wong JYL, Hui X, Xu A*, Lam KSL*. Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice. J Hepatol. 2013 Feb;58(2):358-64.
Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, Itoh N, Wang Y, Bornstein SR, Xu A*, Li X*. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metabolism. 2013;17:779-89 (Cited ~100 times)
Cheng KK, Lam KS, Wu D, Wang Y, Xu A*. APPL1 potentiates insulin secretion in pancreatic beta-cells by increasing Akt-dependent expression of SNARE proteins in mice. Proc. Natl. Acad. Sci. USA. 2012 Jun 5;109(23):8919-24. (Selected for commentary@ Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion. [Proc Natl Acad Sci U S A. 2012])
Li FY, Lam KS, Tse HF, Chen C, Wang Y, Vanhoutte PM, Xu A*. Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice. Circulation. 2012 Sep 4;126(10):1267-77.
Ye D, Li Y, Lam KS, Li H, Jia W, Wang Y, Man K, Li X, Xu A*. TLR4 mediates obesity-induced nonalcoholic steatohepatitis through activation of X-box binding protein in mice. Gut. 2012 Jul; 61(7): 1058-67.
Chang J , Li Y , Huang Y , Lam KS, Hoo LC, Wong WT, Cheng KK, Wang Y, Vanhoutte PM , Xu A*. Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP kinase/p16INK4A Signaling Pathway. Diabetes. 2010 Nov; 59(11): 2949-59.
Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney, Zhu W, Vanhoutte PM, Kraegen EW*, Xu A*. APPL1 Potentiates Insulin-mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice. Cell Metabolism. 2009 May; 9(5):417-27.
Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, Wong RL, Chow WS, Tso AW, Lam KS*, Xu A*. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 2008 May; 57(5):1246-53.
Xu A*, Lam MCL, Chan KW, Wang Y, Hoo RCL, Zhang JL, Tso A and Lam KSL, ANGPTL4 decreases blood glucose, improve glucose tolerance, but induces hyperlipidemia and hepatic steatosis in mice. Proc. Natl. Acad. Sci. USA. 2005 Apr 26; 102(17): 6089-91.
Xu A*, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 2003, 112:91-100. (Selected for the cover story of this issue, Cited over 1148 times)
Professor A Xu
8/F, 21 Sassoon Road, Li Ka Shing Faculty of Medicine, Laboratory Block, Faculty of Medicine Building, Hong Kong SAR, China.
Dr. Gary Sweeney, York University, Canada.
Prof. Edward Kraegen, Garvin's institute, Australia.
Prof. Jia Weiping, Shanghai Diabetes Center, China
RGC Collaborative Research Fund (C7055-14G) - PI
- A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
ITC University-industrial matching fund (UIM/270) -PI
- Development of Innovative Chemiluminescent Immunoassays for Diabetes and its Cardiovascular Complications
NSFC/RGC Joint Research Scheme (N_HKU726/14) – PI
Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance
General Research Fund (HKU17124714) – PIInterplay between Adiponectin and Alternatively-activated Macrophages in Cold-induced Remodeling and Adaptive Thermogenesis of White Adipose Tissues
France ANR/RGC research Scheme (A-HKU-705/13) – PI
- The gut microbiota-adipose tissue axis in the pathogenesis of obesity and its related metabolic disorders: molecular mechanism and clinical implications
General Research Fund (HKU783413M) – PI
- Fibroblast growth factor 21 maintains glucose homeostasis during fasting by mediating the crosstalk between liver and brain
National Key Basic Research Development Program - 973 Program – Co-PI- The Metabolic Syndrome in Chinese: from molecular mechanism to therapeutic intervention
Qatar National Research Fund-QNRF (NPRP 6-428-3-113) – PI
- The protective effects of FGF21 against vascular disease in obesity and diabetes: molecular mechanisms and therapeutic implications
General Research Fund (HKU 782612M) – PI
- The adaptor protein APPL1 as a physiological regulator of insulin secretion in pancreatic cells
RGC collaborative Research Fund (HKU2/CRF/12R) – Co-PI- To Establish a Metabolic Study Center in Hong Kong: Focusing on the Emerging Metabolic Hormones
RGC Collaborative Research Fund (HKU3/CRF/11R) – Co-PI
- Liver Transplantation Research Centre: A Multidisciplinary Study for Liver Graft Injury
Theme-based Research Scheme (T12-705/11) - Co-I
- Personalized medicine for cardiovascular diseases
General Research Fund (784111M) -PI
- The Liver-derived Hormone FGF21 as a Novel Regulator of Vascular Function: Molecular Basis and Physiological Implications
RGC collaborative research fund (HKU4/CRF/10) -PI
- A multiple disciplinary approach to investigate vascular dysfunction in obesity and diabetes: From molecular mechanism to therapeutic intervention
National "973" basic research on diabetes matching fund (2011CB504004) -PI
- 2型糖尿病发生发展的分子机制研究 (Molecular basis of type 2 diabetes).
General Research Fund (783010M) -PI
- APPL2 as a Negative Regulator of Insulin Sensitivity and Glucose Uptake in Skeletal Muscle: A Novel Pathway Leading to Insulin Resistance?
RGC collaborative Research Fund (HKU 3/CRF/09) - Co-I
- To Establish a Metabolic Study Center in Hong Kong: Focusing on the liver-derived hormones
General Research fund (781309M) -PI
- Characterization of Novel Adaptor Proteins Involved in Regulating Insulin Sensitivity and Glucose Homeostasis: from Molecular Mechanism to Physiological Implication
NSFC/RGC joint research scheme 2008 (NHKU 735_08) -PI
- Adipocyte fatty acid binding protein as a novel diagnostic marker and therapeutic target to combat vascular complications of diabetes: mechanisms and clinical implications
General Research Fund 2008 (779608M) -PI
- Protective roles of AMP-activated protein kinase against vascular disease in diabetes: Molecular mechanisms and therapeutic intervention
Antibody and Immunoassay Services