Professor A Xu
Department of Pharmacology & Pharmacy, The University of Hong Kong
Professor Aimin Xu (徐愛民)
BMed Anhui, MSc, PhD Auck
American Diabetes Association
American society of Biochemistry and Molecular Biology HBHA center, HKU
Editor, Biochemical Journal, Clinical Sciences, PLOS ONE
Obesity is a major risk factor for diabetes and cardiovascular disease (CVD). In obese adipose tissue, enlarged adipocytes are infiltrated with activated macrophages, both of which secrete a large number of pro-inflammatory adipokines involved in insulin resistance, endothelial dysfunction and cardiac remodeling. By contrast, the adipocyte production of adiponectin, an insulin-sensitizing adipokine with anti-inflammatory properties, is decreased in obese subjects. Aberrant production of adipokines from adipose tissue is now recognized as an important mediator that links obesity with its medical complications. The primary research focus of our laboratory is to comprehensively study the pathological roles of adipokines in the development of obesity-related insulin resistance, systemic inflammation, diabetes and vascular dysfunctions, from molecular and cellular levels to animal models and human subjects. Our long-term objective is to develop adipokine-based diagnostics and therapeutics for risk prediction and prevention of obesity-induced diabetes and CVD.
Professor Xu and his research associates (click image to enlarge)
Cheng KK, Lam KS, Wu D, Wang Y.. and Xu A*. APPL1 potentiates insulin secretion in pancreatic beta-cells by increasing Akt-dependent expression of SNARE proteins in mice. Proc. Natl. Acad. Sci. USA, 2012, 109:8919-24, selected for commentary.
Li FY, Lam KS, Tse HF, Chen C, Wang Y, Vanhoutte PM, Xu A*. Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice. Circulation. 2012, 126:1267-77.
Tian XY, Wong WT, Xu A*, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y. Uncoupling Protein-2 Protects Endothelial Function in Diet-induced Obese Mice. Circ Res. 2012, 110:1211-6.
Ye D, Li Y, Lam KS, Li H, Jia W, Wang Y, Man K, Li X and Xu A*. TLR4 mediates obesity-induced nonalcoholic steatohepatitis through activation of X-box binding protein in mice. Gut. 2012, 61: 1058-67
Wang Y, Cheng KK, Lam KS, Wu D, Wang Y, Huang Y, Vanhoutte PM, Sweeney G, Li Y, Xu A*. APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes, 2011, 60: 3044-54.
Chen W, Hoo RL, Konishi M, Itoh N, Lee PC, Ye HY, Lam KS, Xu A*. Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes. J. Biol. Chem, 2011, 286:34559-66.
Wong WT, Tian XY, Xu A*, Yu J, Lau CW, Hoo R, Wang Y, Lee VW, Lam KS, Vanhoutte PM, and Huang Y. The obligatory role of adiponectin in restoring endothelial function in PPARγ agonist-treated diabetic mice. Cell Metabolism, 2011, 16:101-15.
Chang J , Li Y , Huang Y , Lam KS, Hoo LC, Wong WT, Cheng KK, Wang Y, Vanhoutte PM , and Xu A*. Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP kinase/p16INK4A Signaling Pathway. Diabetes, 2010, 59: 2949-59
Hui X, Li H, Zhou Z, Lam KS, Xiao Y, Wu D, Ding K, Wang Y, Vanhoutte PM and Xu A*. Adipocyte fatty acid binding protein mediates inflammatory responses in macrophages through a positive feedback loop involving c-Jun N-terminal kinases and activator protein-1. J. Biol. Chem, 2010, 285: 10273-80
Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney, Zhu W, Vanhoutte PM, Kraegen EW and Xu A*. APPL1 Potentiates Insulin-mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice. Cell Metabolism, 2009, 9:417-27.
Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, Wong RL, Chow WS, Tso AW, Lam KS, Xu A*. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes, 2008, 57:1246-53
Xu A*, Lam MCL, Chan KW, Wang Y, Hoo RCL, Zhang JL, Tso A and Lam KSL, ANGPTL4 decreases blood glucose, improve glucose tolerance, but induces hyperlipidemia and hepatic steatosis in mice, Proc. Natl. Acad. Sci. USA, 2005, 102, 6089-6091
Xu A*, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 2003, 112:91-100.The paper was selected for the cover story of this issue.
Professor A Xu
8/F, 21 Sassoon Road, Li Ka Shing Faculty of Medicine, Laboratory Block, Faculty of Medicine Building, Hong Kong SAR, China.
Dr. Gary Sweeney, York University, Canada.
Prof. Edward Kraegen, Garvin's institute, Australia.
Prof. Jia Weiping, Shanghai Diabetes Center, China
Theme-based Research Scheme (T12-705/11) - Co-I
- Personalized medicine for cardiovascular diseases
General Research Fund (784111M) -PI
- The Liver-derived Hormone FGF21 as a Novel Regulator of Vascular Function: Molecular Basis and Physiological Implications
RGC collaborative research fund (HKU4/CRF/10) -PI
- A multiple disciplinary approach to investigate vascular dysfunction in obesity and diabetes: From molecular mechanism to therapeutic intervention
National "973" basic research on diabetes matching fund (2011CB504004) -PI
- 2型糖尿病发生发展的分子机制研究 (Molecular basis of type 2 diabetes).
General Research Fund (783010M) -PI
- APPL2 as a Negative Regulator of Insulin Sensitivity and Glucose Uptake in Skeletal Muscle: A Novel Pathway Leading to Insulin Resistance?
RGC collaborative Research Fund (HKU 3/CRF/09) - Co-I
- To Establish a Metabolic Study Center in Hong Kong: Focusing on the liver-derived hormones
General Research fund (781309M) -PI
- Characterization of Novel Adaptor Proteins Involved in Regulating Insulin Sensitivity and Glucose Homeostasis: from Molecular Mechanism to Physiological Implication
NSFC/RGC joint research scheme 2008 (NHKU 735_08) -PI
- Adipocyte fatty acid binding protein as a novel diagnostic marker and therapeutic target to combat vascular complications of diabetes: mechanisms and clinical implications
General Research Fund 2008 (779608M) -PI
- Protective roles of AMP-activated protein kinase against vascular disease in diabetes: Molecular mechanisms and therapeutic intervention
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